太鼎生物科技/太鼎食安科技

DUB相關抑制劑/WP-1130 貨號#2014-5

WP-1130

A selective DUB (deubiquitinases) inhibitor

WP1130 (degrasyn) is a selective deubiquitinase
(DUB) inhibitor and also inhibits Bcr/Abl with IC50 of 1.8 μM.

Product Name: WP-1130

Alternate Name/Synonyms: (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide;
Degrasyn

Description: Cell-permeable. WP1130 acts as a
partly selective DUB (deubiquitinases) inhibitor, directly inhibiting DUB
activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival
protein stability and 26S proteasome function. WP1130-mediated inhibition of
tumor-activated DUBs results in downregulation of antiapoptotic and
upregulation of proapoptotic proteins, such as MCL-1 and p53. Blocks JAK2
signaling via JAK2 ubiquitination.

Peptide Sequence: N/A

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 856243-80-6

Molecular Formula: C₁₉H₁₈BrN₃O

Molecular Weight: 384.27

Purity: ≥98% by TLC

Solubility: DMSO (40 mg/ml) or EtOH (25 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: Gel pack

Handling: Protect from air and light

【連絡人】許虹宜 0920-312382 Hung-Yi Hsu

【E-mail】taiding.biotech@msa.hinet.net

【公司電話】02-86609496【公司傳真】02-86609342

【相關網址】www.biovision.com

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