【H6N1重組蛋白質HA】#11723-V08H。H6N1 (A/northern shoveler/California/HKWF115/2007) HA Protein 重組蛋白質 @ 太鼎生物科技/太鼎食安科技

H6N 1 HA重組蛋白質

H6N1 (A/northern
shoveler/California/HKWF115/2007) HA Protein 重組蛋白質

產品型號及datasheet: 11723-V08H

H6N1 (A/northern
shoveler/California/HKWF115/2007) HA Protein Product Information

Synonym :	HA
Protein Construction:	A DNA sequence encoding the extracellular domain ( Met 1 - Gln 529 ) of the influenza A H6N1 hemagglutinin (A/northern shoveler/California/ HKWF115/2007 (H6N1) ) (ACE81692.1) (HA1+HA2, uncleaved) was expressed, fused with a C-terminal polyhistidine tag
Source:	Influenza A H6N1
Expression Host:	Human Cells

H6N1
(A/northern shoveler/California/HKWF115/2007) HA Protein QC
Testing

Purity:	> 93 % as determined by SDS-PAGE	SDS-PAGE: H6N 1 HA protein
Endotoxin:	< 1.0 EU per μg of the protein as determined by the LAL method.
Stability:	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal:	Asp 17
Molecular Mass:	The secreted recombinant influenza A H6N 1 HA ( A/northern shoveler/California/HKWF115/2007 (H6N1) ) comprises 524 amino acids and has a predicted molecular mass of 59.2 kDa. As a result of glycosylation, it migrates as an approximately 65 kDa band in SDS-PAGE under reducing conditions.
Formulation:	Lyophilized from sterile PBS , pH 7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

H6N1
(A/northern shoveler/California/HKWF115/2007) HA Protein Usage Guide

Storage:	Store it under sterile conditions at -70℃ . It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

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A/northern
shoveler/California/HKWF115/2007

H6N1 (A/northern shoveler/California/HKWF115/2007) HA Protein Description

Influenza (flu)
is a respiratory infection in mammals and birds. This virus is divided into
three main types (A, B and C). Influenza A is found in a wide variety of bird
and mammal species and is further divided into subtypes based on differences in
the membrane proteins hemagglutinin (HA) and neuraminidase (NA).

H6N1 is a subtype of Influenza A. Hemagglutinin (HA) is a single-pass type
I integral membrane glycoprotein from the influenza virus, and comprises
over 80% of the envelope proteins present in the virus particle. The HA is a
trimer with a receptor binding pocket on the globular head of each monomer. In
natural infection, inactive HA is matured into HA1 and HA2 outside the cell by
one or more trypsin-like, arginine-specific endoprotease secreted by the
bronchial epithelial cells. Binding of HA to sialic acid-containing receptors
on the surface of its target cell brings about the attachment of the virus
particle to the cell and forms a endosome. Low pH in endosomes induce an
irreversible conformational change in HA2, releasing the hydrophobic portion
“fusion peptide”. After which, virus penetrates the cell and pours its contents
including the RNA genome into the cytoplasm mediated by fusion of the
endocytosed virus particle’s own membrane and the endosomal membrane.
Hemagglutinin plays a major role in the determination of host range restriction
and virulence.