H6N 1 HA重組蛋白質
shoveler/California/HKWF115/2007) HA Protein 重組蛋白質
A DNA sequence encoding the
Influenza A H6N1
> 93 % as determined by SDS-PAGE
H6N 1 HA protein
< 1.0 EU per μg of the protein as
Samples are stable for up to twelve
Predicted N terminal:
Store it under sterile conditions at -70℃ . It is recommended that
A hardcopy of COA with reconstitution
is a respiratory infection in mammals and birds. This virus is divided into
three main types (A, B and C). Influenza A is found in a wide variety of bird
and mammal species and is further divided into subtypes based on differences in
the membrane proteins hemagglutinin (HA) and neuraminidase (NA).
H6N1 is a subtype of Influenza A. Hemagglutinin (HA) is a single-pass type
I integral membrane glycoprotein from the influenza virus, and comprises
over 80% of the envelope proteins present in the virus particle. The HA is a
trimer with a receptor binding pocket on the globular head of each monomer. In
natural infection, inactive HA is matured into HA1 and HA2 outside the cell by
one or more trypsin-like, arginine-specific endoprotease secreted by the
bronchial epithelial cells. Binding of HA to sialic acid-containing receptors
on the surface of its target cell brings about the attachment of the virus
particle to the cell and forms a endosome. Low pH in endosomes induce an
irreversible conformational change in HA2, releasing the hydrophobic portion
“fusion peptide”. After which, virus penetrates the cell and pours its contents
including the RNA genome into the cytoplasm mediated by fusion of the
endocytosed virus particle’s own membrane and the endosomal membrane.
Hemagglutinin plays a major role in the determination of host range restriction
Barman, S. et al., 2000, J. Virol. 74:
Suzuki, T. et al., 2005, J. Virol. 79:
Shinya K, et al., 2006,
Nature. 440 (7083): 435-6.
Marjuki, H. et al., 2006, J. Biol.
Chem. 281: 16707-15.
von, Itzstein, M. 2007, Nat. Rev. Drug.
Discov. 6: 967-74.
Christophe F, et al., 2009, Science.