Influenza A H6N 1
HA / Hemagglutinin Antibody
偵測靈敏度: WB (2 ng/lane)
ELISA( 0.039 ng/well
Antibody Type :
Mouse Monoclonal Antibody ( Mouse mAb
Ig Type :
0.2 μm filtered solution in PBS with
Western blot :
This antibody can be used at 1-2
Direct ELISA :
This antibody can be used at 0.5-1
This antibody can be stored at 2℃ -8℃ for one month without
Influenza (flu) is a respiratory infection in mammals and
birds. This virus is divided into three main types (A, B and C). Influenza A is
found in a wide variety of bird and mammal species and is further divided into
subtypes based on differences in the membrane proteins hemagglutinin (HA) and
H6N1 is a subtype of Influenza A. Hemagglutinin (HA) is a single-pass type
I integral membrane glycoprotein from the influenza virus, and comprises
over 80% of the envelope proteins present in the virus particle. The HA is a
trimer with a receptor binding pocket on the globular head of each monomer. In
natural infection, inactive HA is matured into HA1 and HA2 outside the cell by
one or more trypsin-like, arginine-specific endoprotease secreted by the
bronchial epithelial cells. Binding of HA to sialic acid-containing receptors
on the surface of its target cell brings about the attachment of the virus
particle to the cell and forms a endosome. Low pH in endosomes induce an
irreversible conformational change in HA2, releasing the hydrophobic portion
“fusion peptide”. After which, virus penetrates the cell and pours its contents
including the RNA genome into the cytoplasm mediated by fusion of the
endocytosed virus particle’s own membrane and the endosomal membrane.
Hemagglutinin plays a major role in the determination of host range restriction
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