H5N1 Hemagglutinin Protein Datasheet
Influenza A Virus H5N1
>97% as determined by SDS-PAGE.
< 1.0 EU per 1μg of the protein as
Samples are stable for up to twelve
Predicted N terminal:
The secreted recombinant
Store it under sterile conditions at -70℃ . It is recommended that
A hardcopy of COA with
is a respiratory infection in mammals and birds. This virus is divided into
three main types (A, B and C). Influenza A is found in a wide variety of bird
and mammal species. Influenza B is largely confined to humans and is an
important cause of morbidity. Influenza C infects humans, dogs and pigs,
sometimes causing both severe illness and local epidemics. Influenza A is
further divided into subtypes based on differences in the membrane proteins
hemagglutinin (HA) and neuraminidase (NA). The notation HhNn is used to refer
to the subtype comprising the hth discovered HA protein and the nth discovered
NA protein. The HA is a trimer with a receptor binding pocket on the globular
head of each monomer. Subtypes are further divided into strains. Each
genetically distinct virus isolate is usually considered to be a separate
Influenza A virus subtype H5N1, also known as "bird flu", A(H5N1) or
simply H5N1, is a subtype of the Influenza A virus which can cause illness in
humans and many other animal species. H5N1 is easily transmissible between
birds facilitating a potential global spread of H5N1. It is mainly spread by
domestic poultry, both through the movements of infected birds and poultry
products and through the use of infected poultry manure as fertilizer or feed.
Humans with H5N1 have typically caught it from chickens, which were in turn
infected by other poultry or waterfowl. Influenza H5N1 (A/Anhui/1/2005) virus
was isolated from a specimen of tracheal aspirate. The whole genome sequencing
indicated that all segments were of avian origin. The hemagglutinin receptor
binding site was similar to those of other avian H5N1 viruses, and a polybasic
amino acid cleavage site was present.
HA Protein Related Areas:
1. Li KS, et
al., 2004, Nature. 430: 209-213.
2. van RD, et
al., 2006, Science. 312: 399.
3. Shinya K, et
al., 2006, Nature. 440 (7083): 435-436.
JK, et al., 2008, Annu Rev Pathol. 3: 499-522.
F, et al., 2009, Science. 324:1557-1561.