【Galectin-1重組蛋白】 Prospec 重組蛋白。貨號CYT-544 LGALS1、LGALS2、LGALS3、LGALS4、LGALS7、LGALS8、LGALS9 @ 太鼎生物科技/太鼎食安科技

*** --Galectin-1(Gal1)重組蛋白, CYT-544****

Galectin-1(Gal1)是可與β-galactoside
binding 的lectins 蛋白，具有很多的生物功能，像是細胞增生、移動、凋亡、發炎、轉移、免疫調節等。產品貨號# CYT-544, 分有50ug包裝及1mg包裝。

相同字義: Galectin-1, GAL1, GAL-1, Lectin galactoside-binding soluble 1,
Beta-galactoside- binding lectin L-14-I, Lactose-binding lectin 1, S-Lac lectin
1, Galaptin, 14 kDa lectin, HPL, HBL, Putative MAPK-activating protein PM12,
GBP, DKFZp686E23103.

Galectin-1(Gal1)功能介紹

The
galectins are a family of beta-galactoside-binding proteins implicated in
modulating cell-cell and cell-matrix interactions. Galectin-1 is an autocrine
negative growth factor that regulates cell proliferation. Galectin-1 regulates
cell apoptosis and cell differentiation. Galectin-1 binds CD45, CD3 and CD4
& inhibits CD45 protein phosphatase activity and therefore the
dephosphorylation of lyn kinase. Galectin-1 and its ligands are one of the
master regulators of immune responses as T-cell homeostasis and survival,
T-cell immune disorders, inflammation and allergies as well as host–pathogen
interactions. Galectin-1 expression or overexpression in tumors and/or the
tissue surrounding them must be considered as a sign of the malignant tumor
progression that is often related to the long-range dissemination of tumoral
cells (metastasis), to their dissemination into the surrounding normal tissue,
and to tumor immune-escape. Galectin-1 in its oxidized form plays a number of
important roles in the regeneration of the central nervous system after injury.
The targeted overexpression (or delivery) of Galectin-1 should be considered as
a method of choice for the treatment of some kinds of inflammation-related
diseases, neurodegenerative pathologies and muscular dystrophies. In contrast,
the targeted inhibition of Galectin-1 expression is what should be developed
for therapeutic applications against cancer progression. Galectin-1 is thus a
promising molecular target for the development of new and original therapeutic
tools. There is 88% homology between the human and mouse galectin-1.

Galectin-1(Gal1)重組蛋白描述

Description	LGALS1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 134 amino acids and having a molecular mass of 14.5 kDa. The LGALS1 is purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation	The Galectin-1 protein was lyophilized from a concentrated (1mg/ml) containing 10mM sodium phosphate buffer, pH-7.5.
Solubility	It is recommended to reconstitute the lyophilized LGALS1 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability	Lyophilized Galectin-1 Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Galectin-1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Purity	Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Amino acid sequence	ACGLVASNLN LKPGECLRVR GEVAPDAKSF VLNLGKDSNN LCLHFNPRFN AHGDANTIVC NSKDGGAWGT EQREAVFPFQ PGSVAEVCIT FDQANLTVKL PDGYEFKFPN RLNLEAINYM AADGDFKIKC VAFD.
Biological Activity	Human Galectin-1 is a chemoattractant for human blood monocytes. ED50 range is from 0.05–3.0 ug/ml corresponding to a specific activity of 0.3-20MIU/mg.
Protein content	UV spectroscopy at 280 nm using the absorbency value of 0.59 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.