DNA修復基因沉默細胞株(Knockdown cell lines),全新上市。


 


 


在BER路徑中,提供20種以上基因沉默細胞株。包括鹼基切除修復(BER)的途徑、錯配修復(MMR),和非同源末端連接(NHEJ)。特定shRNA慢病毒轉導之LN428膠質母細胞瘤,經由RT-PCR其基因沉默效能為63%~98%。其無特定病毒之污染,品質保證。


 

Tools to Study Genomic Instability and Genotoxic Stress
DNA Repair Gene Knockdown Cell Lines*

DNA repair proteins maintain the stability of the genome. When repair protein function is impaired through mutations, the genome may become unstable which is a hallmark of solid tumors. The availability of this panel of knockdown cell lines will permit scientists to study the molecular etiology of tumor genomic instability and to exploit it in oncology research. The Knockdown line encompasses the Base Excision Repair pathway, Non Homologous End Joining, and Mismatch Repair pathways.


Trevigen’s Knockdown Cell Lines are target specific LN428 (glioblastoma) shRNA lentivirus transduced cells. They are rigorously qualified and mycoplasma free. The percent knockdown levels range from 63-98% as evaluated by RT-PCR. Lentiviruses are maintained by puromycin selection.



FEATURES:

  • Tested negative for Mycoplasma
  • Tested negative for: Human immunodeficiency virus (HIV1, HIV2), Hepatitis viruses (A, B,and C), Human T-lymphotropic virus (HTLV 1, HTLV 2), Epstein Barr, Hantaviruses Hantaan (Seoul, Sin, Nombre), Herpes simplex (1+2,) Human cytomegalovirus, Human herpes virus (6+8), Human adenovirus, Varicella virus and Lymphocytic Choriomeningitis virus.

ORDERING INFORMATION:

  • *Cell lines are provided under an MTA.



 


Base Excision Repair

Catalog #Product Name# of Cells Per VialSize%KD by RT-PCR
5500-001-01PARP1 Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial72%
5502-001-01BRCA1 Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial83%
5504-001-01OGG1 Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial63%
5505-001-01NTHL1 Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial91%
5507-001-01NEIL2 Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial86%
5508-001-01NEIL3 Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial95%
5510-001-01SMUG1 Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial63%
5511-001-01MPG Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial98%
5512-001-01MutYH Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial87%
5513-001-01Neil1 Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial92%
5514-001-01PARP2 Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial83%
5515-001-01PARP3 Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial70%
5516-001-01XRCC1 Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial81%
5517-001-01APE1 Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial90%
5518-001-01APE2 Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial80%
5519-001-01TDG Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial74%
5506-001-01MBD4 Knock Down Cell Line (MTA required before shipment)1x101 vial72


 


Mismatch Repair

Catalog #Product Name# of Cells Per VialSize%KD by RT-PCR
55027-001-01PMS2 Knock Down Cell Line (MTA Required prior to shipment)1x1061 vial84%
55028-001-01MLH3 Knock Down Cell Line (MTA required before shipment)1x1061 vial71%
55021-001-01MSH3 Knock Down Cell Line (MTA required before shipment)1x1061 vial83%
55034-001-01XRCC6 (Ku70) Knock Down Cell Line (MTA required before shipment)1x1061 vial92%
55026-001-01MLH1 Knock Down Cell Lines (MTA required to shipment)1x1061 vial80%
55024-001-01MSH5 Knock Down Cell Line (MTA required to shipment)1x1061 vial92%
55035-001-01XRCC5 (Ku80) Knock Down Cell Line (MTA required before shipment)1x1061 vial85%
55022-001-01MSH6 Knock Down Cell Line (MTA required to shipment)1x1061 vial93%


 


Non-Homologous End Joining

Catalog #Product Name# of Cells Per VialSize%KD by RT-PCR
55037-001-01SIRTI Knock Down Cell Line (MTA required prior to shipment)1x1061 vial95%
55036-001-01PRKDC Knock Down Cell Line (MTA required prior to shipping)1x1061 vial94%
55038-001-01SIRTI2 Knock Down Cell Line (MTA required prior to shipping)1x1061 vial98%


 


Knockdown Control

Catalog #Product Name# of Cells Per VialSize%KD by RT-PCR
5503-001-01Knock Down Control Cell Line (MTA Required prior to shipment)1x1061 vialN/A




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