Salermide
Catalog#: 1873-5 | Size: 5 mg




Salermide,SIRT1SIRT2抑制者。在NAD+-dependent histone deacetylases 扮演基因調控之角色。引發腫瘤專一性凋亡細胞死亡。



The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation. Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~ 20 µM) by reactivating proapototic genes that are repressed by SIRT1. Salermide is a stronger Sirtuin inhibitor than sirtinol.


Alternate Name/Synonyms: N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide


Peptide Sequence: N/A


Appearance: Yellow solid


Formulation: N/A


CAS Number: 1105698-15-4


Molecular Formula: C₂₆H₂₂NO


Molecular Weight: 394.47


Purity: 98


Solubility: DMSO ( 100 mM )


Storage Temp.: -20°C


Shipping Conditions: gel pack


Description: Cell-permeable. Salermide is an inhibitor of SIRT1 and SIRT2. In vitro, Salermide has a stronger inhibitory effect on SIRT2 than on SIRT1. It induces massive apoptosis in tumor cells through reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by SIRT1


Handling: Protect from air and moisture

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