ABT-263, B-細胞淋巴瘤基因Bcl-2抑制劑

Bcl-2, B-細胞淋巴瘤基因, 抑制劑如ABT-265。貨號2467-25

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Product Name: ABT-263 An inhibitor of antiapoptotic Bcl-2 proteins

Alternate Name/Synonyms: (R)-4-(4-((4-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide; Navitoclax

Description: A potent, small molecule Bcl-2 family protein inhibitor (Ki’s of <1 nmol/L for Bcl-2, Bcl-XL and Bcl-w). Displays anticancer properties. Selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and prevents their binding to the apoptotic effectors Bax and Bak proteins, which may trigger apoptosis in tumor cells overexpressing Bcl-2, Bcl-XL, and Bcl-w.

Peptide Sequence: N/A

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 923564-51-6

Molecular Formula: C45H55ClF3N5O6S3

Molecular Weight: 974.61

Purity: ≥98% by HPLC

Solubility:DMSO (> 50 mg/ml)

Storage Temp.: -20 ̊C

Shipping Conditions: gel pack

Handling: Protect from air and light

SMILES: CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

InChi: InChI=1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)/t38-/m1/s1

InChi Key: JLYAXFNOILIKPP-KXQOOQHDSA-N

PubChem CID: 24978538

MDL Number: N/A

USAGE: For Research Use Only! Not For Use in Humans

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