太鼎生物科技/太鼎食安科技

Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | Pirarubicin | Tunicamycin

APExBIO –抗生素化合物系列產品

阿奇霉素 (Azithromycin) | CAS#83905-01-5 APExBIO貨號B1398

Antibiotic by inhibiting protein synthesis

Azithromycin is an antibiotic for inhibition of parasite growth with IC50 of 8.4 μM.

1. Ng MY, Zhang H, et al. "New in Vitro Assay Measuring Direct Interaction of Nonsense Suppressors with the Eukaryotic Protein Synthesis Machinery." ACS Med Chem Lett. 2018 Nov 21;9(12):1285-1291.PMID:30613341
2. Martin Y Ng, Haibo Zhang, et al. "A new in vitro assay measuring direct interaction of nonsense suppressors with the eukaryotic protein synthesis machinery." bioRxiv. 2018 May 24.

Storage	Store at -20°C
M.Wt	748.98
Cas No.	83905-01-5
Formula	C38H72N2O12
Solubility	≥30.05 mg/mL in DMSO; insoluble in H2O; ≥102.8 mg/mL in EtOH
SDF	Download SDF
Canonical SMILES	CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O
Shipping Condition	Ship with blue ice, or upon other requests.
General tips	For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

 

 

APExBIO台灣代理商

APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。

 

Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | Pirarubicin | Tunicamycin

APExBIO –抗生素化合物系列產品

阿奇霉素 (Azithromycin) | CAS#83905-01-5 APExBIO貨號B1398

Antibiotic by inhibiting protein synthesis

Azithromycin is an antibiotic for inhibition of parasite growth with IC50 of 8.4 μM.

1. Ng MY, Zhang H, et al. "New in Vitro Assay Measuring Direct Interaction of Nonsense Suppressors with the Eukaryotic Protein Synthesis Machinery." ACS Med Chem Lett. 2018 Nov 21;9(12):1285-1291.PMID:30613341
2. Martin Y Ng, Haibo Zhang, et al. "A new in vitro assay measuring direct interaction of nonsense suppressors with the eukaryotic protein synthesis machinery." bioRxiv. 2018 May 24.

Storage	Store at -20°C
M.Wt	748.98
Cas No.	83905-01-5
Formula	C38H72N2O12
Solubility	≥30.05 mg/mL in DMSO; insoluble in H2O; ≥102.8 mg/mL in EtOH
SDF	Download SDF
Canonical SMILES	CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O
Shipping Condition	Ship with blue ice, or upon other requests.
General tips	For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

 

 

APExBIO台灣代理商

APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。

 

Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | Pirarubicin

泛艾霉素 (Pirarubicin) | CAS#72496-41-4 APExBIO貨號B2295

 

泛艾霉素(Tunicamycin) Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin. Intercalates into DNA and interacts with Topo II (topoisomerase II) and supressing DNA replication. Pirarubicin is an inhibitor of Topo II. 泛艾霉素(Tunicamycin)是蒽環類(anthracycline)抗腫瘤多柔比星(anti-neoplastic doxorubicin)的類似物。 嵌入 DNA 並與 Topo II（拓撲異構酶 II）相互作用並抑制 DNA 複製(supressing DNA replication)。 Pirarubicin 是 Topo II 的抑制劑。

 

 

1. Krai Daowtak,Suchart Kothan,et al. "In vitro evaluation of P-glycoprotein functions in human neuroblastoma cell lines." Journal of Associated Medical Sciences.Vol 51 No 2 (2018): May-August.

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	627.64
Cas No.	72496-41-4
Formula	C32H37NO12
Solubility	insoluble in H2O; insoluble in EtOH; ≥7.65 mg/mL in DMSO
Chemical Name	7-[4-amino-6-methyl-5-(oxan-2-yloxy)oxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
SDF	Download SDF
Canonical SMILES	CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)OC6CCCCO6
Shipping Condition	Ship with blue ice, or upon other requests.
General tips	For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

APExBIO台灣代理商

APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。

 

太鼎食安科技(bpfood)-成立新網站

https://www.bpfood.com.tw/

太鼎生物科技有限公司成立於生物科技始在台灣嶄露頭角之初，以提供學術單位最專業、最先進技術的實驗設備為我們的核心任務。成立至今，我們憑藉著累積而來的，是有關於自身的專業、經驗的累積，以及大環境的波折損益，一直到目前對於生物科技界能夠有所瞭解，太鼎兢兢業業的態度未曾懈怠。

 

你的食安 太鼎把關！

太鼎是食品安全檢測設備的專業供應商，擁有實驗室等級的分子生物、光學實驗儀器，免疫分析研究領域所需的試劑和設備，技術領先、品質穩定、產品設備齊全。太鼎食安科技是食品安全檢測設備的專，提供3M Petrifilm 檢測試藥: 食品微生物檢測、大腸桿菌檢測、大腸菌群檢測、李氏特菌、3M Petrifilm 金黃色葡萄球菌、3M Petrifilm 沙門氏桿菌檢測等快檢片、ATP微生物冷光儀、水質微生物檢測。擁有實驗室等級的分子生物、光學實驗儀器，免疫分析研究領域所需的試劑和設備，技術領先、品質穩定、產品設備齊全。我們的專業團隊能幫助研究單位計算出精確的數據、臨床檢測的及時需要，提供客戶專業的服務，是太鼎最大的一直以此為職志，並且自豪於此。太鼎的SLOGAN是：「我們或許不是最龐大的供應商，但我們希望成為你最可靠的及時雨」。太鼎以追求專業自期，就如大鼎具深而見廣。太鼎將盡其所能，提供生物科技界眾多先輩後進之需求，為學術發展和良性互動貢獻一份力量。

 

  

 

太鼎食安科技-Bpbood食品安全檢測供應商。代理3M品牌食品安全微生物檢測片、Kikkoman品牌ATP環境檢驗儀及試劑、NEOGEN品牌各式微生物粉狀培養基、ebro溫度監控記錄器、ebro炸油品質檢測儀、Bellingham+Stanley糖度計/鹽度計/屈折度計旋光度計、twinno水質感測器。

 

 

Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | 

APExBIO –抗生素化合物系列產品 衣黴素 (Tunicamycin) | CAS#11089-65-9 APExBIO貨號B7417

antibiotic,inhibits GlcNAc phosphotransferase (GPT)

衣黴素(Tunicamycin)TCM 或 TM）[1] [2] 是一種抗生素。在糖蛋白合成的第一步，它可以阻斷UDP-N-乙醯氨基葡萄糖(UDP-N-acetylglucosamine)與磷酸多甘醇(dolichol phosphate之)間的反應，從而抑制所有N-連接糖蛋白(N-linked glycoproteins)的合成，最終引起內質網(endoplasmic reticulum, ER)應激[3]。在枯草芽孢桿菌細胞(Bacillus subtilis cells)中，中藥抑制多里奇基焦磷酸 N-乙酰氨基葡萄糖 (Dol-p-p-GlcNAc) 形成的 IC50 為 0.03 μg/ml [2]。

ER 應激反應(ER stress response)是對細胞代謝應激(cellular metabolic stress)和錯誤折疊蛋白(misfolded proteins)的一種有效的、進化上保守的反應。內質網應激是由內質網功能的破壞引起的，例如轉運到高爾基複合體(Golgi complex)或蛋白質糖基化(protein glycosylation)，或內質網腔環境的紊亂，例如氧化還原狀態或鈣穩態(calcium homeostasis)的改變 [3]。

 

在 RAW264.7 細胞中，衣黴素(Tunicamycin)顯著降低 LPS 誘導的亞硝酸鹽釋放/產生，並減弱 mRNA 的表達，從而減弱 COX-2 和 iNOS 的蛋白質。此外，濃度為 0.5 μg/ml 的衣黴素(Tunicamycin)對細胞存活/增殖沒有任何影響，但在 48 小時衣黴素(Tunicamycin)提供了針對活化誘導的巨噬細胞死亡的保護作用。衣黴素(Tunicamycin)以濃度依賴性方式降低了響應 LPS 的 COX-2 和 iNOS 蛋白表達，並誘導 78-kDa 葡萄糖調節蛋白 (GRP78) 的同時增加，這是一種 ER 伴侶 [3]。在野生型小鼠的小腸中，衣黴素(Tunicamycin)將抑制的 1370 探針和 1291 探針的表達水平提高了 2 倍以上。在 Nrf 2 (-/-) 小鼠的小腸中，衣黴素抑制 2024 個探針並誘導 3471 個探針超過 2 倍。與小腸樣本的結果相比，在野生型小鼠肝臟中，不太明確的基因被衣黴素(Tunicamycin)抑制 (943) 或升高 (750) >2 倍；而在 Nrf2 (-/-) 小鼠肝臟中，3170 個基因被抑制或 39 個明確定義的基因被誘導 [1]。

 

 

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	844.95
Cas No.	11089-65-9
Formula	C39H64N4O16 (tunicamycin C, n=10)
Solubility	≥25 mg/mL in DMSO
SDF	Download SDF
Shipping Condition	Ship with blue ice, or upon other requests.
General tips	For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

 

APExBIO台灣代理商

APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。

 

 雷帕黴菌（Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | G-418 (80 S 核醣體延伸抑制劑) 

雷帕黴菌（Rapamycin） | CAS#53123-88-9 APExBIO貨號A8167

Original antifungal antibiotic

 

雷帕黴菌（Rapamycin）作為一種原始的抗真菌抗生素，由吸水鏈黴菌(Streptomyces hygroscopicus)生產。由於其免疫抑制作用(immunosuppressive effect)，現已用於預防移植排斥反應。它還表現出對幾種可移植腫瘤(transplantable tumors)的活性和對白血病無活性(inactive against leukemias)具輕微活性。雷帕黴菌（Rapamycin）的免疫抑制作用是通過抑制T細胞的活化(activation)和增殖(proliferation)來發揮的。雷帕黴菌（Rapamycin）與 FK 結合蛋白 12 (FKBP12) 結合併形成雷帕黴素-FKBP12 複合物(rapamycin-FKBP12 complex)，該複合物調節一種在細胞週期(cell cycle)進程中起重要作用的酶。Rapamycin was used as a kind of original antifungal antibiotic, which is produced by Streptomyces hygroscopicus. Now it has been used in the prevention of transplant rejection because of its immunosuppressive effect.  It also exhibits activity against several transplantable tumors and slightly activity to inactive against leukemias. The immunosuppressive effect of Rapamycin is exerted by inhibiting the activation and proliferation of T cells. Rapamycin binds to FK-binding protein 12 (FKBP12) and forms the rapamycin-FKBP12 complex, which regulates an enzyme that plays an important role in the progression of the cell cycle.

 

 

• Purity = 98.00%
• COA (Certificate Of Analysis)
• MS (Mass Spectrometry)
• NMR (Nuclear Magnetic Resonance)
• MSDS (Material Safety Data Sheet)
• Datasheet

 

Physical Appearance	A solid
Storage	Desiccate at -20°C
M.Wt	914.18
Cas No.	53123-88-9
Formula	C51H79NO13
Synonyms	Sirolimus,(-)-Rapamycin, AY-22989, WY-090217, Antibiotic AY22989
Solubility	≥45.7 mg/mL in DMSO; insoluble in H2O; ≥58.9 mg/mL in EtOH with ultrasonic
SDF	Download SDF
Canonical SMILES	O[C@H]1[C@H](OC)C[C@H](C[C@@H](C)[C@H](CC([C@H](C)/C=C(C)/[C@H]([C@@H](OC)C([C@@H](C[C@@H](/C=C/C=C/C=C(C)/[C@@H](OC)C[C@@H]2CC[C@@H](C)[C@@](C(C(N3[C@H]4CCCC3)=O)=O)(O)O2)C)C)=O)O)=O)OC4=O)CC1
Shipping Condition	Ship with blue ice, or upon other requests.
General tips	For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

 

 

• 1. Jialin He, Jianyang Liu, et al. "OM-MSCs Alleviate the Golgi Apparatus Stress Response following Cerebral Ischemia/Reperfusion Injury via the PEDF-PI3K/Akt/mTOR Signaling Pathway." Oxid Med Cell Longev. 2021 Nov 13;2021:4805040. PMID:34815829
• 2. Fang Wang, Jing Zhang, et al. "2-Deoxy-D-glucose impedes T cell-induced apoptosis of keratinocytes in oral lichen planus." J Cell Mol Med. 2021 Nov;25(21):10257-10267. PMID:34672419
• 3. Na Li, Ming Yan. "Extracellular IL-37 promotes osteogenic and odontogenic differentiation of human dental pulp stem cells via autophagy." Exp Cell Res. 2021 Oct 1;407(1):112780. PMID:34411610
• 4. Yuhui Yang, Yiping Huang, et al. "Compressive force regulates cementoblast migration via downregulation of autophagy." J Periodontol. 2021 Nov;92(11):128-138. PMID:34231875
• 5. Xiaoli Liu, Yan Gu, et al. "Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation." Apoptosis. 2021 Apr;26(3-4):195-208. PMID:33550458
• 6. Weiwen Wang, Yan Zhang, et al. "CXCR4 induces cell autophagy and maintains EBV latent infection in EBVaGC." Theranostics. 2020 Sep 18;10(25):11549-11561. PMID:33052232
• 6. Weiwen Wang, Yan Zhang, et al. "CXCR4 induces cell autophagy and maintains EBV latent infection in EBVaGC." Theranostics. 2020 Sep 18;10(25):11549-11561. PMID:33052232
• 7. Liu Y, Li J, et al. "Advanced glycation end-products suppress autophagy by AMPK/mTOR signaling pathway to promote vascular calcification." Mol Cell Biochem. 2020;471(1-2):91-100. PMID:32514882
• 8. Wang J, Chen Y, et al. "mTORC1-IRE1α pathway activation contributes to palmitate-elicited triglyceride secretion and cell death in hepatocytes." Exp Biol Med (Maywood). 2020;1535370220928276. PMID:32436749
• 9. Meng XL, Fu P, et al. "Increased EZH2 Levels in Anterior Cingulate Cortex Microglia Aggravate Neuropathic Pain by Inhibiting Autophagy Following Brachial Plexus Avulsion in Rats." Neurosci Bull. 2020;10.1007/s12264-020-00502-w. PMID:32346844
• 10. Xie X, Yang C, et al. "Advanced glycation end products reduce macrophage-mediated killing of Staphylococcus aureus by ARL8 upregulation and inhibition of autolysosome formation." Eur J Immunol. 2020;10.1002/eji.201948477. PMID:32250445
• 11. Wang F, Zhang J, et al. "The mTOR-glycolytic pathway promotes T-cell immunobiology in oral lichen planus." Immunobiology. 2020;225(3):151933. PMID:32201095
• 12. Zhao F, Wang J, et al. "Neuroprotection by Walnut-derived Peptides through Autophagy Promotion via Akt/mTOR Signaling Pathway against Oxidative Stress in PC12 Cells." J Agric Food Chem. 2020;10.1021/acs.jafc.9b08252.  PMID:32090563
• 13. Xuyang Zhao, Yadong Ma, et al. "mTORC2 mediate FLCN-induced HIF2α nuclear import and proliferation of clear cell renal cell carcinoma." bioRxiv. 2020 January 13.
• 14. Mitchell DC, Menon A, et al. "Cyclin-dependent kinase 4 inhibits the translational repressor 4E-BP1 to promote cap-dependent translation during mitosis-G1 transition." FEBS Lett. 2020 Apr;594(8):1307-1318. PMID:31853978
• 15. WandaNowaka, Leandro NicolásGrendasa, et al. "Pro-inflammatory monocyte profile in patients with major depressive disorder and suicide behaviour and how ketamine induces anti-inflammatory M2 macrophages by NMDAR and mTOR." EBioMedicine. Available online 18 November 2019.
• 16. Liu XH, Liang S, et al. "Metabolomics Analysis Identifies Sphingolipids as Key Signaling Moieties in Appressorium Morphogenesis and Function in Magnaporthe oryzae." MBio. 2019 Aug 20;10(4). pii: e01467-19. PMID:31431550
• 17. Zhang C, Duan Y, et al. "TFEB mediates immune evasion and resistance to mTOR inhibition of renal cell carcinoma via induction of PD-L1." Clin Cancer Res. 2019 Aug 5. pii: clincanres.0733.2019. PMID:31383732
• 18. Li CF, Pan YK, et al. "Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity." Apoptosis. 2019 Jul 29. PMID:31359205
• 19. Ye J, Xue M, et al. "Diosbulbin B-Induced Mitochondria-Dependent Apoptosis in L-02 Hepatocytes is Regulated by Reactive Oxygen Species-Mediated Autophagy." Front Pharmacol. 2019 Jun 19;10:676. PMID:31275148
• 20. Wang Z, Zhang Z, et al. "Polysaccharides from Enteromorpha Prolifera Ameliorate Acute Myocardial Infarction in Vitro and in Vivo via Up-Regulating HIF-1α." Int Heart J. 2019 Jun 28. PMID:31257333
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• 32. Holubova, Kristina, et al. "Rapamycin blocks the antidepressant effect of ketamine in task-dependent manner." Psychopharmacology (2016): 1-21. PMID:27004790
• 33. Hagg A, Colgan TD, et al. "Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size." Sci Rep. 2016 Mar 4;6:23042. PMID:26972746
• 34. Fu J, Ma S, et al. "Long-term Stress with Hyperglucocorticoidemia-induced Hepatic Steatosis with VLDL Overproduction Is Dependent on both 5-HT2 Receptor and 5-HT Synthesis in Liver." Int J Biol Sci. 2016 Jan 1;12(2):219-34. PMID:26884719
• 35. Ranjan, Kishu, and Chandramani Pathak. "Expression of cFLIPL Determines the Basal Interaction of Bcl‐2 with Beclin‐1 and Regulates p53 Dependent Ubiquitination of Beclin‐1 During Autophagic Stress." Journal of cellular biochemistry (2015). PMID:26682748
• 36. Deng, Jiangshan, et al. "Identification of the protective role of DJ-1 in hypoglycemic astrocyte injury using proteomics." Journal of proteome research (2015). PMID:26057206

APExBIO台灣代理商

APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。

 

A3173	AMD-070	558447-26-0	98.00%	CXCR4 antagonist,potent and selective
A3174	AMD-070 hydrochloride	880549-30-4	98.00%	CXCR4 antagonist,potent and selective
A3176	Ampalex	154235-83-3	98.54%	Ampakine and nootropic
A3177	AN-2690	174671-46-6	98.60%	Antifungal agent
A3178	AN-2728	906673-24-3	99.33%	PDE4 inhibitor,anti-inflammatory compound
A3179	Anamorelin	249921-19-5	99.68%	Ghrelin receptor agonist, synthetic, orally active
A3182	Anguizole	442666-98-0	98.00%	Inhibitor of HCV replication
A3184	AR-A014418	487021-52-3	98.34%	GSK3β inhibitor, ATP-competitive and selective
A3185	AR-C155858	496791-37-8	99.52%	MCT1 and MCT2 inhibitor
A3188	ARRY-520 R enantiomer	885060-08-2	98.00%	KSP inhibitor
A3189	AS 602801	848344-36-5	98.72%	Jun Kinase Inhibitor
A3190	ASC-J9	52328-98-0	98.00%	AR degradation enhancer,antiumor agent
A3191	Ascomycin(FK 520)	104987-12-4	98.00%	Macrolide immunosuppressant,FK-520 analog
A3192	Asenapine hydrochloride	1412458-61-7	98.00%	Atypical antipsychotic
A3193	ASP3026	1097917-15-1	99.38%	ALK inhibitor,potent and selective
A3194	AST 487	630124-46-8	99.29%	RET kinase inhibitor
A3195	Asunaprevir (BMS-650032)	630420-16-5	99.80%	NS3 protease inhibitor
A3196	AT-101	90141-22-3	98.00%	BH3-mimetic,gossypol enantiomer
A3197	AT7519 Hydrochloride	902135-91-5	99.80%	Multi-CDK inhibitor
A3198	AT7519 trifluoroacetate	1431697-85-6	98.00%	CDK/cyclin inhibitor
A3199	AT7867 dihydrochloride	1431697-86-7	98.00%	Akt1 and p70S6K/PKA inhibitor
A3201	Atrasentan hydrochloride	195733-43-8	98.00%	Endothelin receptor antagonist
A3202	Avermectin B1	71751-41-2	98.00%	Insecticide
A3206	AVL-292	1202757-89-8	98.27%	Btk inhibitor
A3208	Avosentan	290815-26-8	98.00%	ETA receptor antagonist
A3209	AXL1717	477-47-4	98.07%	IGF-1R inhibitor,orally active
A3210	AZ20	1233339-22-4	99.93%	ATR inhibitor,potent and selective
A3214	AZD1152	722543-31-9	98.78%	Aurora B kinase inhibitor,highly potent and selective
A3215	AZD7687	1166827-44-6	98.00%	DGAT inhibitor,potent and selective
A3216	Balaglitazone	199113-98-9	99.62%	PPAR-γ partial agonist
A3217	Balapiravir	690270-29-2	98.00%	Polymerase inhibitor,anti-HCV
A3218	BAM7	331244-89-4	98.00%	BAX activator,direct and selective
A3219	BAN ORL 24	475150-69-7	98.00%	NOP receptor antagonist, potent and selective
A3220	Bardoxolone	218600-44-3	99.55%	Once-a-day treatment for CKD
A3221	Bardoxolone methyl	218600-53-4	98.75%	IKK inhibitor, potent antioxidant inflammation modulator
A3222	Baricitinib phosphate	1187595-84-1	99.59%	JAK1/JAK2 inhibitor
A3227	BAY 61-3606	732983-37-8	98.45%	Syk Inhibitor
A3228	BAY 61-3606 dihydrochloride	648903-57-5	98.00%	Syk tyrosine kinase inhibitor
A3230	Bay 65-1942 HCl salt	600734-06-3	98.00%	IKKβ kinase inhibitor
A3232	Bazedoxifene	198481-32-2	98.00%	Estrogen receptor modulator
A3236	Benfotiamine	22457-89-2	99.76%	Drug for painful nerve condition
A3237	Betulinic acid	472-15-1	98.00%	Anti-HIV and antitumor compound,pentacyclic triterpenoid
A3238	BEZ235 Tosylate	1028385-32-1	98.28%	MTOR/P13K inhibitor
A3239	B-HT 920	36085-73-1	98.00%	D2 receptor agonist
A3240	BIBX 1382	196612-93-8	98.00%	EGFR inhibitor,potent and selective
A3241	Bilobalide	33570-04-6	98.00%	Neuroprotective agent
A3242	Bitopertin	845614-11-1	99.70%	Glycine reuptake inhibitor(GlyT1)
A3244	Bivalirudin Trifluoroacetate	128270-60-0	98.07%	Reversible thrombin inhibitor
A3246	BMN-673 8R,9S	1207456-00-5	99.75%	Inactive form of BMN 673, used as negative control
A3248	BMS345541 hydrochloride	547757-23-3	99.57%	IKK inhibitor,highly selective
A3250	BMS-509744	439575-02-7	98.00%	Itk inhibitor,potent and selective
A3252	BMS-599626 Hydrochloride	873837-23-1	99.58%	EGFR/HER2 inhibitor,potent and selective
A3253	BMS-626529	701213-36-7	98.01%	HIV-1 attachment inhibitor
A3254	BMS-663068	864953-29-7	98.00%	HIV-1 attachment inhibitor
A3256	BMS-690514	859853-30-8	98.00%	HER/EGFR inhibitor
A3257	BMS-790052 dihydrochloride	1009119-65-6	99.81%	HCV NS5A inhibitor
A3258	BMS-833923	1059734-66-5	99.84%	Smoothened inhibitor
A3259	BMS-927711	1289023-67-1	98.99%	CGRP receptor antagonist
A3260	BMX-IN-1	1431525-23-3	97.99%	BMX (also termed ETK) kinase inhibitor
A3261	Boceprevir	394730-60-0	98.00%	HCV protease inhibitor,potent and selective
A3263	BRAF inhibitor	918505-61-0	98.00%	Potent B-raf inhibitor
A3264	B-Raf inhibitor	1315330-11-0	98.00%	A B-Raf inhibitor
A3265	Brassinolide	72962-43-7	98.00%	Plant growth regulator
A3266	BS-181	1092443-52-1	98.00%	CDK7 inhibitor,highly selective
A3268	CAL-130 Hydrochloride	1431697-78-7	98.00%	PI3K inhibitor
A3270	Calcifediol monohydrate	63283-36-3	99.43%	Prehormone;vitamin D3 metabolite
A3271	Calcipotriol	112965-21-6	98.00%	Vitamin D3 analog,regulates cell differentiation and proliferation
A3275	Calcium-Sensing Receptor Antagonists I	478963-79-0	98.00%	CaSR antagonist
A3276	Canertinib dihydrochloride	289499-45-2	99.72%	Pan-ErbB inhibitor, potent and selective
A3277	Capadenoson	544417-40-5	98.00%	Adenosine A1 receptor agonist
A3278	Nonivamide (Capsaicin Analog)	2444-46-4	99.53%	TRPV1 receptor agonist
A3279	Capsazepine	138977-28-3	99.25%	TRPV1 ion channel antagonist
A3282	Cariprazine	839712-12-8	99.19%	D2/D3 partial agonist,antipsychotic drug
A3284	Cathepsin S inhibitor	1373215-15-6	98.33%	Blocks MHCII antigen presentation
A3285	CB 300919	289715-28-2	98.00%	Potential therapy for ovarian cancer
A3286	CB30865	206275-15-2	98.00%	Nampt inhibitor
A3287	CC-401 hydrochloride	1438391-30-0	98.00%	JNK inhibitor
A3288	CC-930	899805-25-5	98.00%	JNK inhibitor,potent and selective
A3289	CCG-63802	620112-78-9	98.00%	RGS protein inhibitor
A3290	CCG-63808	620113-73-7	98.00%	Reversible RGS inhibitor
A3291	CCT241533	1262849-73-9	98.00%	Potent Chk2 inhibitor
A3292	CCT241533 hydrochloride	1431697-96-9	98.00%	CHK2 kinase inhibitor, novel
A3293	CDK inhibitor II	1269815-17-9	98.00%	CDK inhibitor
A3294	CDK9 inhibitor	1415559-43-1	98.00%	CDK9 inhibitor
A3295	CDK9 inhibitor 2	1263369-28-3	98.00%	CDK9 inhibitor
A3297	CEP-32496 hydrochloride	1227678-26-3	98.00%	B-Raf/C-Raf inhibitor,highly potent
A3297	CEP-32496 hydrochloride	1227678-26-3	98.00%	B-Raf/C-Raf inhibitor,highly potent
A3298	Cetirizine	83881-51-0	99.65%	Antihistamine
A3300	Cevimeline hydrochloride hemihydrate	153504-70-2	98.00%	Agonist of muscarinic receptor (M1/M3)
A3302	CGI-1746	910232-84-7	98.00%	Btk inhibitor
A3303	CGP60474	164658-13-3	98.00%	CDKs and PKC inhibitor, potent
A3304	CGS 21680	120225-54-9	98.00%	Adenosine A2 receptor agonists,potent and selective
A3305	CHAPS	75621-03-3	97.71%	Zwitterionic detergent for membrane proteins,nondenaturing
A3306	Chelerythrine Chloride	3895-92-9	99.36%	PKC antagonist
A3307	CHIR-090	728865-23-4	99.37%	Potent LpxC inhibitor
A3308	Choline Fenofibrate	856676-23-8	99.92%	Choline salt of fenofibric acid
A3309	CHR-6494	1333377-65-3	98.00%	Haspin inhibitor,potent ands selective
A3310	chroman 1	1273579-40-0	98.00%	ROCK II inhibitor, highly potent and selective
A3311	CID-2858522	758679-97-9	98.00%	NF-κB pathway inhibitor
A3313	Cinacalcet	226256-56-0	99.48%	Calcimimetic agent,orally active
A3314	Cinaciguat	329773-35-5	98.00%	Soluble guanylate cyclase (sGC) activators
A3315	Clemizole	442-52-4	99.06%	H1 histamine receptor antagonist
A3316	Clemizole hydrochloride	1163-36-6	99.73%	H1 histamine receptor antagonist
A3317	Clozapine N-oxide (CNO)	34233-69-7	99.74%	Metabolite of clozapine, used in chemogenetics.
A3319	CMK	821794-90-5	98.00%	RSK2 kinase inhibitor
A3320	CO-1686 (AVL-301)	1374640-70-6	99.28%	EGFR inhibitor
A3321	Cobimetinib	934660-93-2	99.71%	Selective MEK inhibitor
A3322	Cobimetinib (racemate)	934662-91-6	98.00%	Selective MEK inhibitor
A3331	CP-809101 hydrochloride	1215721-40-6	98.00%	5-HT2C receptor agonist, potent and selective
A3334	CTS-1027	193022-04-7	98.00%	MMPs inhibitor
A3335	Curcumin	458-37-7	98.36%	Tyrosinase inhibitor
A3336	CVT-313	199986-75-9	98.04%	Cdk2 inhibitor
A3337	CX-6258	1202916-90-2	98.28%	Pan-Pim kinases Inhibitor
A3339	CYT387 sulfate salt	1056636-06-6	98.00%	JAK1/JAK2 inhibitor
A3340	CZC24832	1159824-67-5	98.00%	Selective PI3K-γ inhibitor
A3342	D4476	301836-43-1	99.22%	CK1/ALK5 inhibitor,specific and cell permeable
A3343	D609	83373-60-8	98.00%	PC-PLC inhibitor
A3344	D-64131	74588-78-6	98.00%	Tubulin polymerization inhibitor
A3345	Dabigatran etexilate mesylate	872728-81-9	99.41%	Direct thrombin inhibitor,anticoagulant,prodrug of dabigatran
A3346	Dabigatran ethyl ester	429658-95-7	98.00%	Thrombin activity inhibitor
A3347	Dabrafenib Mesylate (GSK-2118436)	1195768-06-9	99.78%	Inhibitor of BRAF(V600) mutants
A3348	Daminozide	1596-84-5	98.00%	KDM2A inhibitor
A3349	Darapladib	356057-34-6	99.54%	Lp-PLA2 inhibitor, selective and orally active
A3351	Dasatinib hydrochloride	854001-07-3	99.91%	Multi-BCR/Abl and Src kinase inhibitor, oral active
A3352	Daun02	290304-24-4	98.00%	Cell viability inhibitor,DNA synthisis inhibitor
A3353	DB07268	929007-72-7	98.84%	JNK1 inhibitor
A3355	Deferasirox Fe3+ chelate	554435-83-5	98.00%	Oral iron chelator
A3356	Delafloxacin	189279-58-1	99.81%	Fluoroquinolone antibiotic
A3357	Delafloxacin meglumine	352458-37-8	98.00%	Fluoroquinolone antibiotic agent
A3358	Deltarasin	1440898-61-2	98.00%	KRAS-PDEδ interaction inhibitor
A3359	Desmopressin	16679-58-6	98.66%	Hemostatic and anti-diuretic
A3360	Desmopressin Acetate	62288-83-9	98.73%	Synthetic analogue of arginine vasopressin
A3363	DGAT-1 inhibitor	701232-20-4	99.64%	Diacylglycerol acyltransferase (DGAT1) inhibitor
A3366	Dipraglurant	872363-17-2	98.00%	mGluR5 antagonist
A3368	DMAT	749234-11-5	98.60%	CK2 inhibitor,potent and selective
A3369	DMP 777	157341-41-8	98.00%	Leukocyte elastase (HLE) inhibitor
A3370	Docetaxel Trihydrate	148408-66-6	99.78%	Depolymerisation of microtubules inhibitor
A3371	Doramectin	117704-25-3	97.08%	Antiparasitic antibiotic
A3374	Dronedarone	141626-36-0	99.58%	CYP3A4 and 2D6 inhibitor,moderate
A3375	DY131	95167-41-2	99.82%	ERRγ agonist
A3378	E-3810	1058137-23-7	98.00%	VEGF/FGF dual inhibitor, potent and selective
A3380	Ebrotidine	100981-43-9	98.00%	H2-receptor antagonist,competitive
A3381	Edoxaban	480449-70-5	99.27%	Factor Xa inhibitor
A3383	Edoxaban tosylate monohydrate	1229194-11-9	99.34%	Oral factor Xa inhibitor
A3384	Elacridar	143664-11-3	98.17%	BCRP inhibitor
A3385	Elacridar hydrochloride	143851-98-3	98.00%	BCRP and P-GP inhibitor
A3387	Eltrombopag Olamine	496775-62-3	98.49%	C-mpl agonist
A3389	EMD638683	1181770-72-8	98.46%	SGK1 inhibitor
A3392	Emodin	518-82-1	99.09%	Naturally occurring anthraquinone,antiproliferative
A3394	Epothilone D	189453-10-9	98.00%	Natural polyketide compound
A3395	Ercalcidiol	21343-40-8	98.00%	Vitamin D2 metabolite,ligand of VDR-like receptors
A3396	Ercalcitriol	60133-18-8	98.00%	Active metabolite of vitamin D2
A3397	Erlotinib	183321-74-6	99.47%	EGFR tyrosine kinase inhibitor
A3399	Esomeprazole Magnesium trihydrate	217087-09-7	98.32%	Proton pump inhibitor
A3401	Etifoxine hydrochloride	56776-32-0	99.87%	GABAA receptor potentiator
A3403	Etofenamate	30544-47-9	98.05%	Non-steroidal anti-inflammatory drug
A3404	Etomoxir	124083-20-1	99.75%	(CPT)-1 and DGAT activity inhibitor
A3405	Etoricoxib	202409-33-4	99.82%	Specific COX-2 inhibitor
A3407	EVP-6124 hydrochloride	550999-74-1	99.85%	Alpha7 nAChR agonist
A3408	Exendin-4	141758-74-9	99.66%	GLP-1 activator
A3411	Faropenem daloxate	141702-36-5	98.00%	Oral penem,beta-lactam antibiotic
A3412	Fenretinide	65646-68-6	98.00%	Synthetic retinoid agonist
A3413	FH535	108409-83-2	99.62%	Wnt/B-catenin inhibitor
A3415	Firategrast	402567-16-2	99.56%	α4β1/α4β7 integrin antagonist
A3416	FK 3311	116686-15-8	98.00%	Selective COX-2 inhibitor
A3417	Flavopiridol	146426-40-6	99.52%	Pan-cdk inhibitor
A3418	Flecainide acetate	54143-56-5	99.82%	Antiarrhythmic drug
A3419	Fluvastatin	93957-54-1	98.33%	HMGCR inhibitor
A3420	FMK	821794-92-7	98.82%	RSK inhibitor
A3421	Fosamprenavir Calcium Salt	226700-81-8	99.71%	Prodrug of antiretroviral protease inhibitor amprenavir
A3423	Galanthamine	357-70-0	99.12%	Acetylcholinesterase inhibitor
A3424	Gambogic Acid	2752-65-0	98.54%	Caspase activator and apoptosis inducer
A3429	GANT 58	64048-12-0	99.38%	GLI antagonist,novel and potent
A3432	GDC-0941 dimethanesulfonate	957054-33-0	99.78%	PI3K inhibitor
A3433	Gefitinib hydrochloride	184475-55-6	99.87%	Potent EGFR inhibitor
A3434	Genz-644282	529488-28-6	98.00%	Non-camptothecin inhibitor of topoisomerase I
A3435	glucagon receptor antagonists 1	503559-84-0	98.00%	Glucagon receptor antagonist,highly potent
A3436	glucagon receptor antagonists 2	202917-18-8	98.00%	Glucagon receptor antagonist,highly potent
A3437	glucagon receptor antagonists 3	202917-17-7	98.00%	Glucagon receptor antagonist
A3438	Glucocorticoid receptor agonist	1245526-82-2	98.00%	Glucagon receptor antagonist
A3440	Glyoxalase I inhibitor	221174-33-0	98.00%	Glyoxalase I inhibitor
A3441	GPR120 modulator 1	1050506-75-6	98.00%	GPR120 modulator
A3442	GPR120 modulator 2	1050506-87-0	98.00%	GPR120 modulator
A3443	Granisetron	109889-09-0	98.00%	Serotonin 5-HT3 receptor antagonist
A3444	GS-9620	1228585-88-3	98.01%	TLR-7 agonist
A3445	GSK 525768A	1260530-25-3	98.00%	inactive stereoisomer of I-BET-762
A3446	GSK126	1346574-57-9	98.32%	EZH2 inhibitor
A3448	GSK2606414	1337531-36-8	98.18%	PERK inhibitor,potent and selective
A3449	GSK343	1346704-33-3	98.95%	EZH2 inhibitor,potent,selective and cell permeable
A3450	GSK-923295	1088965-37-0	98.28%	CENP-E inhibitor,small-molecule
A3451	Guanfacine hydrochloride	29110-48-3	99.41%	α2A-adrenoceptor agonist
A3452	GW-1100	306974-70-9	98.00%	GPR40 antagonist
A3453	GW1929	196808-24-9	98.00%	Potent PPARγ agonist
A3454	GW3965	405911-09-3	98.00%	HLXRα/hLXRβ agonist,potent and selective
A3456	GW843682X	660868-91-7	98.00%	PLK1/PLK3 inhibitor,potent and selective
A3460	HhAntag	496794-70-8	98.95%	GLI1-mediated transcription inhibitor
A3461	HIV-1 integrase inhibitor	544467-07-4	98.00%	Uesful for anti-HIV
A3465	HOE 33187	23623-08-7	98.00%	Blue fluorescent dyes
A3466	Hoechst 33258	23491-45-4	99.88%	Blue fluorescent dyes
A3472	Hoechst 33342	875756-97-1	98.84%	Blue fluorescent dyes

雷帕黴菌（Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | G-418 (80 S 核醣體延伸抑制劑)

APExBIO –抗生素化合物系列產品 amphipathic polyene antibiotic

兩性黴素 B (Amphotericin B) | CAS# 1397-89-3 APExBIO貨號B1885

兩性黴素 B(Amphotericin B) 是一種多烯類抗真菌抗生素(polyene antifungal antibiotic)，由結節鏈黴菌菌株(Streptomyces nodosus)生產，IC50 為 0.028–0.290 μg/ml。體外試驗：兩性黴素 B(Amphotericin B)  是治療許多危及生命的真菌感染(fungal infections)最有效的藥物。在表達 TLR2 和 CD14 的細胞中，兩性黴素 B(Amphotericin B)  誘導信號轉導(signal transduction)和炎性細胞因子釋放(inflammatory cytokine release)。在表達 TLR2、CD14 和銜接蛋白 MyD88 的原代鼠巨噬細胞(primary murine macrophages)和人類細胞株中，兩性黴素 B(Amphotericin B)誘導 NF-κB 依賴性報告基因活性和細胞因子釋放，而缺乏任何這些的細胞都沒有反應。與表達正常 TLR4 的細胞相比，具有 TLR4 突變的細胞對兩性黴素 B(Amphotericin B)刺激的反應較弱 

兩性黴素 B(Amphotericin B)  可與膽固醇(cholesterol)（哺乳動物細胞膜的主要甾醇）相互作用，因此由於其相對較高的毒性而限制了兩性黴素 B(Amphotericin B)  的用途 [2]。低 AmB 濃度 (≤ 0.1 μM) 在懸浮在等滲蔗糖溶液中的 KCl 負載脂質體中誘導極化電位，表明 K+ leakage。 AmB (＞ 0.1 μM) 允許陽離子和陰離子運動。懸浮在等滲 NaCl 溶液中並暴露於 AmB (0.05 μM) 的 LP 表現出幾乎完全的負膜電位collapse，表明 Na+ 進入了細胞 [3]。

 

References:

[1]. Sau K1,Mambula SS,Latz E,Henneke P,Golenbock DT,Levitz SM.The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism.J Biol Chem.2003 Sep 26;278(39):37561-8. Epub 2003 Jul 14.

[2]. Demaimay R1,Adjou K,Lasmézas C,Lazarini F,Cherifi K,Seman M,Deslys JP,Dormont D.Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie.J Gen Virol.1994 Sep;75 ( Pt 9):2499-503.

Storage	Store at -20°C
M.Wt	924.08
Cas No.	1397-89-3
Formula	C47H73NO17
Solubility	≥46.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
SDF	Download SDF
Canonical SMILES	O=C(C[C@@H](C[C@@H](CC[C@@H](O)[C@@H]1O)O)O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@H]2[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O2)C[C@@H]([C@H](C(O)=O)[C@@H](O)C3)OC3(O)C[C@H](C1)O
Shipping Condition	Ship with blue ice, or upon other requests.
General tips	For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

 

APExBIO台灣代理商

APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。

 

太鼎食安科技(bpfood)-成立新網站

https://www.bpfood.com.tw/

 

 

你的食安 太鼎把關！

太鼎是食品安全檢測設備的專業供應商，擁有實驗室等級的分子生物、光學實驗儀器，免疫分析研究領域所需的試劑和設備，技術領先、品質穩定、產品設備齊全。太鼎食安科技是食品安全檢測設備的專，提供3M Petrifilm 檢測試藥: 食品微生物檢測、大腸桿菌檢測、大腸菌群檢測、李氏特菌、3M Petrifilm 金黃色葡萄球菌、3M Petrifilm 沙門氏桿菌檢測等快檢片、ATP微生物冷光儀、水質微生物檢測。擁有實驗室等級的分子生物、光學實驗儀器，免疫分析研究領域所需的試劑和設備，技術領先、品質穩定、產品設備齊全。我們的專業團隊能幫助研究單位計算出精確的數據、臨床檢測的及時需要，提供客戶專業的服務，是太鼎最大的一直以此為職志，並且自豪於此。太鼎的SLOGAN是：「我們或許不是最龐大的供應商，但我們希望成為你最可靠的及時雨」。太鼎以追求專業自期，就如大鼎具深而見廣。太鼎將盡其所能，提供生物科技界眾多先輩後進之需求，為學術發展和良性互動貢獻一份力量。

 

  

 

太鼎食安科技-Bpbood食品安全檢測供應商。代理3M品牌食品安全微生物檢測片、Kikkoman品牌ATP環境檢驗儀及試劑、NEOGEN品牌各式微生物粉狀培養基、ebro溫度監控記錄器、ebro炸油品質檢測儀、Bellingham+Stanley糖度計/鹽度計/屈折度計旋光度計、twinno水質感測器。

 

細胞遷移 | Cell Migration Assay Kit (24 well,8μM)貨號KTA5010

活動期間2022/10/01-2022/12/31 (來電洽詢0920312382許虹宜) 

Cell Migration Assay Kit

產品描述：

細胞遷移(Cell migration)是指細胞受外界信號刺激，從一個地方遷移(migrate到)另一個地方的特性。另一種，通常發生在傷口癒合(wound healing)、細胞分化(cell differentiation)、胚胎發育(embryonic development)和腫瘤轉移(tumor metastasis等)過程中。Transwell 是一種實驗技術，可以在體外模擬人體的許多黏膜(mucosal)和生物屏障系統(biological barrier systems)。這該技術的主要材料是 Transwell 小室，Abbkine Cell Migration Assay Kit (24-Well Plate, 8 µm) 使用聚碳酸酯膜（polycarbonate membrane,  8 µm 孔徑）來測量細胞的遷移特性(migration characteristics)。原理是把Transwell將小室放入培養板中，小室稱為上室，培養板內部稱為下室腔室，上下層培養基由聚碳酸酯膜（polycarbonate membrane,  8 µm 孔徑）隔開。聚碳酸酯膜（polycarbonate membrane,  8 µm 孔徑）是可滲透的，下層培養基中的成分會影響上層的細胞。通過染色(staining)和洗脫(elution)，計數細胞數以反映細胞的遷移能力(migration ability)。

活細胞和死細胞雙染色套組  |  CCK-8細胞增殖和細胞毒性試劑盒  | LDH細胞毒性測定試劑盒 | 細胞衰老檢測試劑盒（β-半乳糖苷酶 | 細胞增殖EdU Image試劑盒 

 

Product name	Cell Migration Assay Kit (24 well,8μM)
Applications notes	Cell Migration Assay Kit (24 well,8μM) is used to detect cell migration with relative accuracy.
Kit components	•24-Well Migration Plate •Fixation Solution •Staining Solution •Elution Solution
Features & Benefits	• Easy to operate. • Simple, optimized experimental method. • To detect the migration ability of cells.
Storage instructions	Refer to list of materials supplied for storage conditions of individual components. Stable for at least 6 months at recommended temperature from date of shipment.
Shipping	Gel pack with blue ice.
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

 

貨號	產品名稱	胞器染色位置	螢光波段
貨號KTC4003	TraKine™粒線體染色	粒線體(mitochondria)	Ex / Em = 490/523 nm	增殖(proliferating)和非增殖細胞(non-proliferating cells)
貨號KTC4100	Pro活細胞微管蛋白染色	微管蛋白(Tubulin)	Ex/Em = 500/520 nm	活細胞或固定之細胞
貨號KTC4001	Abbkine 細胞膜染色	細胞膜 (plasma membrane)	Ex/Em = 484/501 nm	活細胞、固定懸浮、貼附細胞
貨號BMD00063	DAPI Staining Solution	細胞核 dsDNA	Ex/Em: 358/461 nm (with DNA)	染色活細胞和固定細胞
貨號KTC4210	活細胞Lysosome染色	Lysosome	deep red fluorescent dye , Ex/Em:650/665nm	染色活細胞和固定細胞

 

雷帕黴菌（Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | G-418 (80 S 核醣體延伸抑制劑) 

β - 半乳糖苷酶  | β – Galactosidase CAS#7240-90-6  APExBIO  貨號A2539

β - 半乳糖苷酶 (β – Galactosidase) 的底物，可產生豐富的藍色，可在背景中輕鬆檢測到。選擇具有 lac + 基因型 (lac + genotype) 的重組細菌菌落的藍/白選擇底物(blue/white selection)。以 20mg/ml 溶解於二甲基甲醯胺 (AB00450) 或 DMSO (AB00435) 。Substrate for β - Galactosidase which produces a rich blue color that can easily be detected visually over background. Substrate of choice for blue/white selection of recombinant bacterial colonies with the lac + genotype. dissolve in dimethylformamide (AB00450) or DMSO (AB00435) at 20mg/ml X-GAL (sizes 100mg, 250mg, 500mg, 1g) is supplied with a vial of freshly distilled DMF to ensure optimum color development store at -20°C。

 

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	408.63
Cas No.	7240-90-6
Formula	C14H15BrCINO6
Solubility	insoluble in H2O; ≥109.4 mg/mL in DMSO; ≥3.7 mg/mL in EtOH with gentle warming and ultrasonic
Chemical Name	(2S,3R,4S,5R,6R)-2-[(5-bromo-4-chloro-1H-indol-3-yl)oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
SDF	Download SDF
Canonical SMILES	C1=CC(=C(C2=C1NC=C2OC3C(C(C(C(O3)CO)O)O)O)Cl)Br
Shipping Condition	Ship with blue ice, or upon other requests.
General tips	For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

 

 

APExBIO台灣代理商

APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。

 

品項	CAS#	#貨號	應用
Z-VAD-FMK	CAS# 187389-52-2	貨號 A1902	Proteases ICE-like proteases
TAPI-1	CAS#171235-71-5	貨號 B4686	Proteases TACE/ADAM17 inhibitor Product Citation+3
Talabostat mesylate	CAS# 150080-09-4	貨號B3941	Proteases DPP4 二肽基肽酶特異性抑制劑
Z-IETD-FMK	CAS# 210344-98-2	貨號B3232	inhibitor of caspase 8
Cisplatin	CAS# 15663-27-1	貨號A8321	高效、廣譜的化療藥物
17-DMAG (Alvespimycin) HCl	CAS#467214-21-7	貨號A2213	Hsp90 inhibitor
CA-074 Me	CAS# 147859-80-1	貨號A8239	Cathepsin B inhibitor
VX-765	CAS# 273404-37-8	貨號A8238	Caspase-1 inhibitor

 

雷帕黴菌（Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | G-418 (80 S 核醣體延伸抑制劑) 

JNJ-26854165 (Serdemetan) | CAS# 881202-45-5 APExBIO  貨號A4204

Product Citation+1

P53 activator, blocking Mdm2-p53 interaction

JNJ-26854165，也稱為 Serdemetan，最初是作為 p53 的激活劑(activator)開發的，現在被認為是一種新型的口服 Human Double Minute-2 (HDM-2) 泛素連接酶拮抗劑(ubiquitin ligase antagonist)。它可以通過抑制 HDM-2-客戶蛋白複合物(HDM-2-client protein complex)與蛋白酶體的結合來增加 HDM-2 client proteins的水平，例如 p53。在廣泛的 p53 野生型和突變型腫瘤模型中，JNJ-26854165 顯示出有效的抗增殖和凋亡誘導活性。在體內，與對照相比，JNJ-26854165 在 37 個實體瘤中的 18 個和可評估的 ALL 異種移植物(xenografts)中的 7 個中的 5 個中可能引起 EFS 分佈的重要差異。

1. Chen R, Zhou J, et al. "A Fusion Protein of the p53 Transaction Domain and the p53-Binding Domain of the Oncoprotein MdmX as an Efficient System for High-Throughput Screening of MdmX Inhibitors." Biochemistry. 2017 Jun 27;56(25):3273-3282.PMID:28581721

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	328.41
Cas No.	881202-45-5
Formula	C21H20N4
Synonyms	JNJ 26854165
Solubility	insoluble in EtOH; insoluble in H2O; ≥14.8 mg/mL in DMSO
Chemical Name	1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine
SDF	Download SDF
Canonical SMILES	C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4
Shipping Condition	Ship with blue ice, or upon other requests.
General tips	For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

 

APExBIO台灣代理商

APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。

A7010	Fmoc-Cl	28920-43-6
A7012	Fmoc-Osu	82911-69-1
A7015	BOP reagent	56602-33-6
A7017	CDI (1,1′-Carbonyldiimidazole)	530-62-1
A7018	DCC	538-75-0
A7021	EDC.HCl	25952-53-8
A7022	HATU	148893-10-1
A7023	HBTU	94790-37-1
A7024	HOAt	39968-33-7
A7025	HOBt	2592-95-2
A7026	HOOBt	28230-32-2
A7027	HCTU	330645-87-9
A7029	PyBOP	128625-52-5
A7032	TBTU	125700-67-6
A7041	HMP Linker	68858-21-9
A7042	Rink Amide Linker	145069-56-3
A7043	Ramage Linker,Fmoc-Suberol	212783-75-0
A7046	AMC	26093-31-2
A7052	DBU	6674-22-2
A7053	Diethyl Acetamidomalonate	1068-90-2
A7055	DMAP	1122-58-3
A7058	5-Ethyltio-1H-Tetrazole	89797-68-2
A7059	HOSu	6066-82-6
A7061	Tetrazole	288-94-8
A7070	H-D-Ala-OBzl·TosOH	41036-32-2
A7088	L-NAME hydrochloride	51298-62-5
A7093	H-D-Arg-NH2•2HCl	203308-91-2
A7132	H-Cys-OH	52-90-4
A7143	H-Cys(Trt)-OH	2799-07-7
A7158	Bz-Glu-OH	6094-36-6
A7170	H-Glu(OEt)-OEt·HCl	1118-89-4
A7175	H-Glu(OtBu)-OtBu·HCl	32677-01-3
A7231	H-Lys(Ac)-OH.HCl	1820580-06-0
A7232	H-Lys(Boc)-OH	2418-95-3
A7237	H-Lys(Z)-OH	1155-64-2
A7270	H-Phe-pNA	2360-97-6
A7281	H-Pro-OtBu	2812-46-6
A7291	H-Ser-OH	56-45-1
A7294	H-Ser-OBzl.HCl	1738-72-3
A7295	H-Ser(Bzl)-OH	4726-96-9
A7300	Fmoc-Ala-OH	35661-39-3
A7301	Fmoc-Ala-OMe	146346-88-5
A7306	Fmoc-Arg-OH	91000-69-0
A7308	Fmoc-Arg(Pbf)-OH	154445-77-9
A7331	Z-Ala-OH	1142-20-7
A7349	Boc-Asp-OtBu	34582-32-6
A7352	Fmoc-Arg(Tos)-OH	83792-47-6
A7357	Fmoc-Asn(Trt)-OH	132388-59-1
A7361	Fmoc-Asp-OH	119062-05-4
A7362	Fmoc-Asp-OAll	144120-53-6
A7364	Fmoc-Asp-OtBu	129460-09-9
A7380	H-Ser(tBu)-OBzl.HCl
A7441	H-Val-OtBu.HCl	13518-40-6
A7460	Fmoc-Cha-OH	135673-97-1
A7482	Fmoc-D-Phe(4-Cl)-OH	142994-19-2
A7486	H-Cit-OH	372-75-8
A7493	H-D-Dab-OH•2HCl	127531-11-7
A7498	Fmoc-Dap(Boc)-OH	162558-25-0
A7499	Fmoc-D-Tyr(4-Et)-OH
A7522	Boc-N-Me-Ala-OH	16948-16-6
A7526	Fmoc-N-Me-Asp(OtBu)-OH	152548-66-8
A7527	Fmoc-N-Me-Glu(OtBu)-OH	200616-40-6
A7528	Fmoc-N-Me-Ile-OH	138775-22-1
A7529	H-N-Me-Leu-OBzl.TosOH	42807-66-9
A7530	H-D-N-Me-Leu-OBzl.TosOH	1208162-98-4
A7531	H-Phe(4-F)-OH	1132-68-9
A7539	H-D-Phe(2-F)-OH.HCl	122839-51-4
A7541	Boc-ß-HoAla-OH	158851-30-0
A7542	Fmoc-ß-HoAla-OH	193954-26-6
A7543	H-HoArg-OH	156-86-5
A7544	Boc-HoArg(NO2)-OH	28968-64-1
A7583	H-HoSer-OH	672-15-1
A7599	Fmoc-Hyp-OH	88050-17-3
A7656	H-DL-Nva-OH	760-78-1
A7658	Fmoc-Oic-OH	130309-37-4
A7704	Z-N-Me-Ala-OH	21691-41-8
A7705	Fmoc-N-Me-Leu-OH	103478-62-2
A7706	Fmoc-D-N-Me-Leu-OH	103478-63-3
A7707	Boc-D-N-Me-Phe.DCHA	102185-45-5
A7708	Boc-N-Me-Phe.DCHA	40163-88-0
A7709	Z-N-Me-Phe-OH	2899-07-2
A7710	Boc-N-Me-Phg-OH	30925-11-2
A7711	Boc-D-N-Me-Phg-OH
A7712	H-N-Me-Pro-OH	475-11-6
A7713	H-N-Me-Ser-OH.HCl	2480-26-4
A7714	Boc-N-Me-Ser(tBu)-OH	1313054-71-5
A7715	Fmoc-N-Me-Ser(tBu)-OH	197632-77-2
A7716	Fmoc-N-Me-Thr(tBu)-OH	117106-20-4
A7717	Boc-N-Me-Tyr-OH.DCHA	95105-25-2
A7718	Boc-N-Me-Tyr(Bzl)-OH	64263-81-6
A7719	Fmoc-N-Me-Tyr(tBu)-OH	133373-24-7
A7720	H-N-Me-D-Val-OH.HCl	210830-32-3
A7721	Boc-N-Me-Val-OH	45170-31-8
A7722	Fmoc-N-Me-Val-OH	84000-11-3
A7723	Fmoc-D-N- Me-Val-OH	103478-58-6
A7724	Z-D-N-Me-Val-OH
A7728	Boc-Asp-OBzl	30925-18-9
A7740	Boc-D-Asp(OtBu)-OH.DCHA	200334-95-8
A7775	Boc-His(Dnp)-OH	25024-53-7
A7786	Boc-Lys-OH	13734-28-6
A7815	Boc-Pro-OH	15761-39-4
A7829	Boc-Ser(tBu)-OH.DCHA	18942-50-2
A7862	Fmoc-Asp(OtBu)-OH	71989-14-5
A7874	Fmoc-Cys(Trt)-OH	103213-32-7
A7881	Fmoc-Gln(Trt)-OH	132327-80-1
A7882	Fmoc-Gln(Trt)-OPfp	132388-65-9
A7884	Fmoc-D-Gln(Trt)-OH	200623-62-7
A7895	Fmoc-Glu(OtBu)-OH	71989-18-9
A7896	Fmoc-Glu(OtBu)-OPfp	86061-04-3
A7901	Fmoc-Gly-OH	29022-11-5
A7902	Fmoc-Gly-OPfp	86060-85-7
A7904	Fmoc-His(Trt)-OH	109425-51-6
A7908	Fmoc-Ile-OH	71989-23-6
A7909	Fmoc-Ile-OPfp	86060-89-1
A7912	Fmoc-Leu-OH	35661-60-0
A7913	Fmoc-Leu-OPfp	86060-88-0
A7914	Fmoc-D-Leu-OH	114360-54-2
A7916	Fmoc-Lys-OH	105047-45-8
A7918	Fmoc-Lys(2-Cl-Z)-OH	133970-31-7
A7922	Fmoc-Lys(Boc)-OH	71989-26-9
A7926	Fmoc-Lys(Dnp)-OH	148083-64-1
A7927	Fmoc-Lys(ivDde)-OH	204777-78-6
A7928	Fmoc-Lys(Fmoc)-OH	78081-87-5
A7930	Fmoc-Lys(Mtt)-OH	167393-62-6
A7935	Fmoc-D-Lys(Boc)-OH	92122-45-7
A7939	Fmoc-Met-OH	71989-28-1
A7947	Fmoc-Phe-OH	35661-40-6
A7948	Fmoc-Phe-OPfp	86060-92-6
A7952	Fmoc-Pro-OH	71989-31-6
A7956	Fmoc-Ser-OH	73724-45-5
A7959	Fmoc-Ser(HPO3Bzl)-OH	158171-14-3
A7960	Fmoc-Ser(tBu)-OH	71989-33-8
A7967	Fmoc-Thr-OH	73731-37-0
A7971	Fmoc-Thr(tBu)-OH	71989-35-0
A7975	Fmoc-D-Thr(tBu)-OH	138797-71-4
A7977	Fmoc-Trp-OH	35737-15-6
A7979	Fmoc-Trp(Boc)-OH	143824-78-6
A7985	Fmoc-O-Phospho-Tyr-OH	147762-53-6
A7989	Fmoc-Tyr(tBu)-OH	71989-38-3
A7993	Fmoc-Val-OH	68858-20-8
A7994	Fmoc-Val-OPfp	86060-87-9
A8001	Sulfo-NHS-Biotin	119616-38-5
A8002	NHS-Biotin	35013-72-0
A8003	Sulfo-NHS-LC-Biotin	127062-22-0
A8004	NHS-LC-Biotin	72040-63-2
A8005	Sulfo-NHS-SS-Biotin	325143-98-4
A8006	NHS-SS-Biotin	122266-55-1
A8007	Biotin Hydrazide	66640-86-6
A8008	Biotin-HPDP	129179-83-5
A8009	Iodoacetyl-LC-Biotin	93285-75-7
A8010	Biotin	58-85-5
A8011	Biotin-tyramide	41994-02-9
A8012	Biotin-XX Tyramide Reagent
A8013	Biotin-azide	908007-17-0
A8015	Sulfo-NHS-SS-11-Biotin
A8016	NHS-SS-11-Biotin	142439-92-7
A8019	Perindopril Erbumine	107133-36-8

 

最新消息!! 太鼎食安科技-成立新網站

 

 

太鼎生物科技有限公司成立於生物科技始在台灣嶄露頭角之初，以提供學術單位最專業、最先進技術的實驗設備為我們的核心任務。成立至今，我們憑藉著累積而來的，是有關於自身的專業、經驗的累積，以及大環境的波折損益，一直到目前對於生物科技界能夠有所瞭解，太鼎兢兢業業的態度未曾懈怠。太鼎食安科技-Bpbood食品安全檢測供應商。代理3M品牌食品安全微生物檢測片、Kikkoman品牌ATP環境檢驗儀及試劑、NEOGEN品牌各式微生物粉狀培養基、ebro溫度監控記錄器、ebro炸油品質檢測儀、Bellingham+Stanley糖度計/鹽度計/屈折度計旋光度計、twinno水質感測器。

 

你的食安 太鼎把關！

太鼎是食品安全檢測設備的專業供應商，擁有實驗室等級的分子生物、光學實驗儀器，免疫分析研究領域所需的試劑和設備，技術領先、品質穩定、產品設備齊全。太鼎食安科技是食品安全檢測設備的專，提供3M Petrifilm 檢測試藥: 食品微生物檢測、大腸桿菌檢測、大腸菌群檢測、李氏特菌、3M Petrifilm 金黃色葡萄球菌、3M Petrifilm 沙門氏桿菌檢測等快檢片、ATP微生物冷光儀、水質微生物檢測。擁有實驗室等級的分子生物、光學實驗儀器，免疫分析研究領域所需的試劑和設備，技術領先、品質穩定、產品設備齊全。我們的專業團隊能幫助研究單位計算出精確的數據、臨床檢測的及時需要，提供客戶專業的服務，是太鼎最大的一直以此為職志，並且自豪於此。太鼎的SLOGAN是：「我們或許不是最龐大的供應商，但我們希望成為你最可靠的及時雨」。

太鼎以追求專業自期，就如大鼎具深而見廣。太鼎將盡其所能，提供生物科技界眾多先輩後進之需求，為學術發展和良性互動貢獻一份力量。

  

 

 

雷帕黴菌（Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | G-418 (80 S 核醣體延伸抑制劑) 

 

Chromatin/Epigenetics系列產品+

可加入官方LINE或連絡信箱 (按此) 或來電0920312382許小姐

 

  

 

表觀遺傳學(Epigenetics)是基因表達的可遺傳修飾(heritable modifications)，與 DNA 序列(DNA sequence)的變化無關。表觀遺傳修飾(Epigenetic modifications)主要發生在 DNA 或組蛋白八聚體(histone octamer)上。有幾種類型的表觀遺傳學修飾(epigenetics modifications)，DNA-甲基轉移酶 (DNMT) 的 DNA 甲基化和組蛋白的共價修飾，例如乙醯化(acetylation)、甲基化(methylation)、磷酸化(phosphorylation)和泛素化(ubiquitination)。組蛋白乙醯轉移酶 (HAT) 的組蛋白乙醯化參與轉錄啟動，而組蛋白去乙醯化酶 (HDAC) 的組蛋白去乙醯化與轉錄抑制(transcriptional repression)有關。組蛋白去甲基化(Histone demethylation)與賴氨酸特異性去甲基化酶 (lysine-specific demethylase , LSD) 和含有組蛋白去甲基化酶 (JHDM) 的 JmjC 結構域(JmjC domain)有關。核小體(nucleosome)由四種組蛋白（H2A、H2B、H3 和 H4）組成，它們是染色質(chromatin)的主要組成部分。特定化學基團的添加和去除稱為表觀遺傳標記(epigenetic marks)，它調節染色質結構並影響基因表達。此外，RNA 與抑制性染色質狀態(repressive chromatin state)的形成密切相關。表觀遺傳(Epigenetic)機制在細胞水準上響應環境變化，從而影響細胞可塑性(plasticity)。染色質(Chromatin)和表觀遺傳調控(epigenetic regulation)在發育和應激反應期間的基因組編程中發揮重要作用，表觀遺傳學缺陷(defects in epigenetics)可導致癌症(cancer)、炎症(inflammation)和代謝紊亂(metabolic disorders)等。

MG 149 | CAS# 1243583-85-8 APExBIO  貨號B3276HAT inhibitor

Product Citation+2

HAT inhibitor

MG 149 是一種組蛋白乙醯轉移酶 (histone acetyltransferases , HAT) 抑制劑，對 Tip60 和 MOF 的 IC50 值分別為 74μM 和 47μM [1]。MG 149 是漆樹酸衍生物(anacardic acid derivative)。它顯示對 MYST 類型的 HAT：Tip60 和 MOF 的選擇性抑制，IC50 值分別為 74μM 和 47μM。docking study表明，MG 149 對 Tip60 的抑制作用相對於 Tip60 的 Ac-CoA 結合口袋中的 Ac-CoA 具有競爭性。 MG 149 還使用生物素化組蛋白 H3 (biotinylated histone H3)或組蛋白 H4 肽(histone H4 peptides)作為底物抑制 HeLa 細胞核提取物中 HAT 的活性。與組蛋白 H4 (histone H4)相比，它被發現對組蛋白 H3 (histone H3)更有效。此外，DNA 微陣列顯示 MG149 抑制 p53 和 NF-kB 通路以及數量非常有限的其他通路 [1, 2]。

 

1. Zichong Li. "Functional characterization of transcription elongation machinery in HIV transcription and latency." University of California. 2019.
2. Li Z, Mbonye U, et al. "The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency." PLoS Pathog. 2018 Apr 23;14(4):e1007012.PMID:29684085

 

Storage	Store at RT
M.Wt	340.46
Cas No.	1243583-85-8
Formula	C22H28O3
Solubility	≥114 mg/mL in DMSO; ≥30.5 mg/mL in EtOH; insoluble in H2O
Chemical Name	2-(4-heptylphenethyl)-6-hydroxybenzoic acid
SDF	Download SDF
Canonical SMILES	CCCCCCCC1=CC=C(CCC2=C(C(O)=O)C(O)=CC=C2)C=C1
Shipping Condition	Ship with blue ice, or upon other requests.
General tips	For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

 

APExBIO台灣代理商

APExBIO提供優質的勝肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。

 

GTPase分析套組產品介紹 

Innova Biosciences 提供之GTPase分析套組，可探討酵素活性是否扮演transport、signal transduction,protein biosynthesis及cell differentiation之角色。應用於GTPase活性分析。提供high-throughput screen 大量GTPase inhibitor。可建立快速藥物篩選系統。內附有GTPase inhibitor。GTPase酵素活性分析，採用超高靈敏度Malachite green磷酸根呈色方法，克服傳統呈色方法,低靈敏度限制。測量目標樣本中， GTPases酵素活性

GTPases酵素活性之分析

產品特點

1. 提供high-throughput screen 大量GTPase inhibitor

2. GTPase酵素分析套組，包括stabilizing solution，可避開acid labile substrate所造成的高背景值，其背景值很低(
1mM )。

3. 其分析波段為600~660nm，避開一般colored compounds之干擾。

4. Pi-dye複合物極為穩定，其訊號強度可維持數小時之久。

5. Superior呈色系統。採用Malachite Green磷酸根呈色方式，呈色靈敏度比傳統呈色方法高，克服低靈敏度的限制。

6. 適用於大部份的assay buffer。

7. 蛋白質濃度高時，不會抑制顏色的形成。

-------------------------------

產品內容物

1 x 10ml of PiColorLock™ Gold* (1 x 25ml)

1 x 0.25ml of Accelerator (1 x 0.5ml)

1 x 5ml of Stabiliser (1 x 10ml)

1 x 1.5ml of 0.1M MgCl2 (2 x 1.5ml)

1 x 5ml of 0.5M Tris pH 7.5 (1 x 10ml)

1 x 5ml of 0.1mM Pi standard (1 x 10ml)

更多參考內容: 原廠連結: http://www.innovabiosciences.com/

 

訂購貨號# 602-0120,196 assays (靈敏度4~40uM)

訂購貨號# 602-0121,480 assays (靈敏度4~40uM)

訂購貨號# 602-0122,480*5 assays (靈敏度4~40uM)

 

GTPase酵素活性分析套組---文獻發表

GTPase酵素活性分析套組

 

The selenocysteine-specific elongation factor
contains a novel and multi-functional domain - The
Journal of Biological Chemistry (2012)

 

Tubulin nucleotide status controls Sas-4-dependent
pericentriolar material recruitment - Nature Cell
Biology (2012)

 

The Mitochondrial Phosphatase PGAM5 Functions at
the Convergence Point of Multiple Necrotic Death Pathways
- Cell (2012)

 

Leucyl-tRNA Synthetase Is an Intracellular
Leucine Sensor for the mTORC1-Signaling Pathway - Cell
(2012)

 

• ArfGAP1 Is a GTPase Activating Protein for
  LRRK2: Reciprocal Regulation of ArfGAP1 by LRRK2 - Journal
  of Neuroscience (2012)

 

GTPase Activity and Neuronal Toxicity of
Parkinson's Disease–Associated LRRK2 Is Regulated by ArfGAP1
- PLoS Genetics (2012)

 

AIP1 Functions as Arf6-GAP to Negatively
Regulate TLR4 Signaling - JBC (2010)

 

GTPase activity plays a key role in the
pathobiology of LRRK2 - PLoS Genetics (2010)

 

Role of the
G-protein and tyrosine kinase—Rho/ROK pathways in
15-hydroxyeicosatetraenoic acid induced pulmonary vasoconstriction in
hypoxic rats - J Biochem (2010)

 

AIP1 Functions as Arf6-GAP to Negatively
Regulate TLR4 Signaling - JBC (2010)

 

Identification and Characterization of a
Leucine-Rich Repeat Kinase 2 (LRRK2) Consensus Phosphorylation Motif
- PLoS One (2010)

 

Speckled-like Pattern in the Germinal Center
(SLIP-GC), a Nuclear GTPase Expressed in Activation-induced
Deaminase-expressing Lymphomas and Germinal Center B Cells
- JBC (2009)

 

High-level production and characterization of a
G-protein coupled receptor signaling complex -
FEBS Journal (2009)

 

Structure of ERA in
complex with the 3′ end of 16S rRNA: Implications for ribosome biogenesis
-
PNAS (2009)

 

G Protein-Coupled Receptor-Promoted Trafficking
of Gβ1γ2 Leads to AKT Activation at Endosomes via a Mechanism Mediated by
Gβ1γ2-Rab11a Interaction – Molecular Biology of
the Cell (2008)

 

Characterization
of Human GTPBP3, a GTP-Binding Protein Involved in Mitochondrial tRNA
Modification - Molecular and Cellular Biology
(2008)

 

Comparative real-time PCR and enzyme analysis of
selected gender-associated molecules in Schistosoma japonicum
- Parasitology (2008)

更多相關諮詢請洽

台灣代理廠商: 太鼎生物科技有限公司

業務代表: 許虹宜 0920312382 email: taiding.biotech@msa.hinet.net

公司電話: 02-86609496傳真: 02-86609342
公司網站: www.biopioneer.com.tw

 

癌化特性之分析套組-Tube formation kit

trevigen提供 Cultrex® In Vitro Angiogenesis Assay Kit ，可以偵測血管細胞血管形成之inducers及inhibitors分析。微孔板上預包埋Trevigen專利的BME基質及其它組分蛋白，具有極低的細胞毒性，經嚴格的無細菌/真菌/支原體等驗證，接近真實體內環境；螢光定量具更高的精準度

 

Cultrex® In Vitro Angiogenesis Assay Tube Formation Kit

Catalog #: 3470-096-K 體外血管新生分析套組

 

癌化過程中具有血管新生之過程，藉以提供癌細胞養份及氧氣。血管新生作用是由內皮細胞所引導的。過程中細胞會分泌酵素來分解基底膜，造成細胞之遊走，經由一連串的增生分化後，最後形成管狀般的血管構造。trevigen提供 Cultrex® In Vitro Angiogenesis Assay Kit ，可以偵測血管細胞血管形成之inducers及inhibitors分析。

Cultrex^® In Vitro Angiogenesis Assay Tube Formation Kit

 

Under permissive
conditions, endothelial cells respond by self organizing into structures that
resemble microvessels or tubes. Trevigen's Cultrex® In Vitro Angiogenesis Assay
Kit allows for the detection of inducers and inhibitors of endothelial cell tube
formation. Cultrex^® Reduced Growth Factor (RGF) Basement Membrane
Extract (BME) is a soluble form of basement membrane purified from
Engelbreth-Holm-Swarm (EHS) tumor, which gels at room temperature to form a
reconstituted protein matrix comprised mainly of laminin, collagen IV,
entactin, and heparin sulfate proteoglycan. Sulforaphane [1-
isothiocyanato-(4R)- methylsulfinyl)-butane], found in broccoli and other
cruciferous vegetables, is a naturally occurring cancer chemopreventive agent,
and is provided as a control for inhibition of in vitro endothelial cell tube
formation on Cultrex^® RGF BME. Calcein AM is provided for rapid and
accurate measurement of cell viability and/or cytotoxicity, and kinetic
analysis of tube formation. Trevigen's Cultrex^® In Vitro
Angiogenesis Assay Kit provides a cost-effective method for investigation of
prospective angiogenesis inhibitors in a 96 well plate format.

 

COMPONENTS:

Basement Memrane Extract (BME) growth (3433-005-01)
factor reduced

Calcein AM  (螢光顯微鏡)

Cell staining solution (倒立顯微鏡/相位差顯微鏡)

Sulphoraphane 10mM

100 µM Sulforaphane working solution

 

REFERENCES:

 

1. Folkman J.
2007. Angiogenesis: an organizing principle for drug discovery? Nat. Rev. Drug
Discov. 6:273-286.

2. Jaffe EA, Nachman RL, Becker CG, Minick CR. 1973. Culture of human
endothelial cells derived from umbilical veins. J. Clin. Invest. 52:2745-2756.

3. Folkman J, Haudenschild C. 1980. Angiogenesis in vitro. Nature 288:551- 556.

4. Kleinman HK, McGarvey ML, Hassell JR, Star VL, Cannon FB, Laurie GW, Martin
GR. 1986. Basement membrane complexes with biological activity. Biochemistry
25:312-318.

5. Lawley TJ, Kubota Y. 1989. Induction to morphologic differentiation of
endothelial cells in culture. J. Invest. Dermatol. 93:59S-61S.

6. Ucuzian AA, Greisler HP. 2007. In vitro models of angiogenesis. World J.
Surg. 31:654-663.

7. Salcedo R, Zhang X, Young HA, Michael N, Wasserman K, Ma W-H, Martins-Green
M, Murphy WJ, Oppenheim JJ. 2003. Angiogenic effects of prostaglandin E2 are
mediated by up-regulation of CXCR4 on human microvascular endothelial cells.
Blood 102:1966-1977.

8. Mochizuki M, Philp D, Hozumi K, Suzuki N, Yamada Y, Kleinman HK, Nomizu M.
2007. Angiogenic activity of syndecan-binding laminin peptide AG73
(RKRLQVQLSIRT). Arch. Biochem. Biophys. 459:249-255.

9. Arnaoutova, I. , J. George, H.K. Kleinman,
and G. Benton. 2009. The endothelial cell tube formation assay on basement
membrane turns 20: state of the science and the art. Angiogensis. 12(3):267-74.

10. Arnaoutova I, and Kleinman HK. 2010. In vitro angiogenesis: endothelial
cell tube formation on gelled basement membrane extract. Nat Protoc.
5(4):628-35.

 

 

 

Kit Components:

 

更多原廠資料連結

http://www.trevigen.com/item/274/Cultrex_In_Vitro_Angiogenesis_Assay_Tube_Formation_Kit/ 

Trevigen的Cultrex體外血管生成分析試劑盒可進行內皮細胞管形成誘導劑和抑制劑的檢測.不含生長因數（RGF）的BME是從EHS腫瘤中純化出的可溶形式基底膜，其在室溫條件下凝固形成由層連蛋白、Ⅳ型膠原蛋白、Entactin蛋白以及肝素硫酸鹽糖蛋白形成的重構蛋白基質.在花椰菜和其他十字花科蔬菜中發現的萊菔硫烷，是一種天然的癌症化學抑制劑，被用於體外內皮細胞在Cultrex BME上血管形成的抑制劑陰性對照.鈣黃綠素-AM用於快速準確檢測細胞的生存能力和/或細胞毒性，以及血管形成的即時動力學分析.Trevigen Cultrex體外血管生成分析試劑盒以96孔方式為檢測潛在的血管生成抑制劑提供高效的方案.

 

ROCK抑制劑(A Rho kinase) 體用包裝5mg

 

品牌BIOVISION/貨號#1784-5/ 包裝5MG (純度>98%)

Y-27632為ROCK (A Rho kinase)之抑制劑。Y-27632 is a cell-permeable, highly potent and selective inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK). Y-27632 inhibits both ROCKI (K_i = 220 nM) and ROCKII (K_i = 300 nM) by competing with ATP for binding to the catalytic site. (Davies et al., Ishizaki et al.)

 

Y-27632產品應用

體外試驗或體內試驗, 抑制ROCK酵素活性

 

Y-27632產品提供

Liquid 10mM (5MG) 純度>98%

 

Y-27632產品內容相關

 

內容相關http://www.biovision.com/ezsolution-y-27632-4248.html

Product Name: EZSolution™ Y-27632

Alternate Name/Synonyms: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecar boxamide dihydrochloride

Description: A 10 mM (5 mg in 1550 µl) solution of Y-27632, Dihydrochloride (Cat. No. 1596-5) in deionized water.

Peptide Sequence: N/A

Appearance: Liquid

Formulation: 10 mM (H₂O)

CAS Number: 146986-50-7

Molecular Formula: C₁₄H₂₁N₃O.2HCl

Molecular Weight: 320.26

Purity: ≥98% by HPLC

Solubility:N/A

Storage Temp.: -20°C

Shipping Conditions: gel pack

Handling: Protect from air and light

SMILES: CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl

InChi: InChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11?,12?;;/m1../s1

InChi Key: IDDDVXIUIXWAGJ-DDSAHXNVSA-N

PubChem CID: 9901617

MDL Number: MFCD03490488

USAGE: For Research Use Only! Not For Use in Humans.

 

其它抑制劑相關如下連結

免疫抑制劑商品>>>>

http://taiding2000.pixnet.net/blog/post/19556158

Bcl-2抑制劑商品>>>>

http://taiding2000.pixnet.net/blog/post/329072982  

 

更多相關諮詢請洽

台灣代理廠商: 太鼎生物科技有限公司

公司電話: 02-86609496 /0920312382
公司傳真: 02-86609342
公司網站: www.biopioneer.com.tw

連絡業務: 許虹宜 0920312382
連絡信箱: taiding.biotech@msa.hinet.net

 

 

ABT-263, B-細胞淋巴瘤基因Bcl-2抑制劑

Bcl-2, B-細胞淋巴瘤基因, 抑制劑如ABT-265。貨號2467-25

Product Name: ABT-263 An inhibitor of antiapoptotic Bcl-2 proteins

Alternate Name/Synonyms: (R)-4-(4-((4-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide; Navitoclax

Description: A potent, small molecule Bcl-2 family protein inhibitor (Ki’s of <1 nmol/L for Bcl-2, Bcl-XL and Bcl-w). Displays anticancer properties. Selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and prevents their binding to the apoptotic effectors Bax and Bak proteins, which may trigger apoptosis in tumor cells overexpressing Bcl-2, Bcl-XL, and Bcl-w.

Peptide Sequence: N/A

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 923564-51-6

Molecular Formula: C₄₅H₅₅ClF₃N₅O₆S₃

Molecular Weight: 974.61

Purity: ≥98% by HPLC

Solubility:DMSO (> 50 mg/ml)

Storage Temp.: -20 ̊C

Shipping Conditions: gel pack

Handling: Protect from air and light

SMILES: CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

InChi: InChI=1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)/t38-/m1/s1

InChi Key: JLYAXFNOILIKPP-KXQOOQHDSA-N

PubChem CID: 24978538

MDL Number: N/A

USAGE: For Research Use Only! Not For Use in Humans

 

商品如下連結

WWW.BIOVISION.COM

http://www.biovision.com/abt-263-7866.html

 

相關諮詢請洽

台灣代理廠商: 太鼎生物科技有限公司
公司電話: 02-86609496 /0920312382
公司傳真: 02-86609342
公司網站: www.biopioneer.com.tw
連絡業務: 許虹宜 0920312382
連絡信箱: taiding.biotech@msa.hinet.net

 

Rapamycin 免疫抑制劑, 5g

Rapamycin

Catalog#: 1568-5  | Size: 5
mg

Rapamycin作用

Rapamycin，雷帕黴素，是新型大環內酯的抗排斥藥物，是目前世界上最新的強效免疫抑制劑，臨床上用於器官移植的抗排斥反應和自身免疫性疾病的治療。可能通過阻斷IL-2啟動的T細胞增殖而選擇性抑制T細胞，用於抗移植排斥反應。2009年7月的《Nature》雜誌上，文章Rapamycin fed from 20 months of
age extends lifespan in genetically heterogeneous mice，研究顯示此類藥物能延長酵母菌、線蟲、果蠅等無脊椎動物的壽命。(資料來源http://www.ebiotrade.com/newsf/2010-2/2010223171552934.htm)

 

 

產品資料

Alternate
Name/Synonyms: 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine,
AY 22989, Sirolimus

Appearance: Off-white solid

Formulation: N/A

CAS Number: 53123-88-9

Molecular
Formula: C₅₁H₇₉NO₁₃

Molecular
Weight: 914.19

Purity: ≥99%

Solubility: DMSO and EtOH

Storage Temp.: -20°C

Shipping
Conditions: gel
pack

Description: An immunosuppressant.
Selectively blocks signaling that leads to p70 S6 kinase activation (IC50 = 50
pM). Inhibits lymphokine-induced cell proliferation at the G1 phase. Induce apoptosis
in a murine B cell line. Rapamycin has been used in vivo studies by i.p., i.m.,
and i.v. administrations..

Handling: Protect from light and
moisture

 

bIOVISON之相關產品

Apoptosis
Detection Kits & Reagents

 Annexin V Kits & Bulk Reagents

 Caspase Assay Kits & Reagents

 Mitochondrial Apoptosis Kits & Reagents

 Nuclear Apoptosis Kits & Reagents

 Apoptosis Inducers & Inhibitors

 Apoptosis siRNA
Vectors

 

Cell
Fractionation System

 Mitochondria/Cytosol Fractionation Kit

 Nuclear/Cytosol Fractionation Kit

 Membrane Protein Extraction Kit

 Cytosol/Particulate Rapid Separation Kit

 Mammalian Cell Extraction Kit

 FractionPREP
Fractionation System

 

Cell
Proliferation & Senescence

 Quick Cell Proliferation Assay Kit

 Senescence Detection Kit

 High Throughput Apoptosis/Cell Viability Assay Kits

 LDH-Cytotoxicity Assay Kit

 Bioluminescence Cytotoxicity Assay Kit

 Live/Dead Cell
Staining Kit

 

Cell
Damage & Repair

 HDAC Fluorometric & Colorimetric Assays &
Drug Discovery Kits

 HAT Colorimetric Assay Kit & Reagents

 DNA Damage Quantification Kit

 Glutathione &
Nitric Oxide Fluorometric & Colorimetric Assay Kits

 

Signal
Transduction

 cAMP & cGMP Assay Kits

 Akt & JNK Activity Assay Kits

 Beta-Secretase
Activity Assay Kit

 

Adipocyte
& Lipid Transfer

 Recombinant Adiponectin, Survivin, & Leptin

 CETP Activity Assay & Drug Discovery Kits

 PLTP Activity Assay & Drug Discovery Kits

 Cholesterol
Quantification Kit

 

Molecular
Biology & Reporter Assays

 siRNA Vectors

 Cloning Insert Quick Screening Kit

 Mitochondrial & Genomic DNA Isolation Kits

 5 Minutes DNA Ligation Kit

 20 Minutes Gel
Staining/Destaining Kit

 

Growth
Factors and Cytokines (many)

Polyclonal and
Monoclonal Antibodies

 

【連絡人】許虹宜 0920-312382 Hung-Yi Hsu

【E-mail】taiding.biotech@msa.hinet.net

【公司電話】02-86609496【公司傳真】02-86609342

【公司網址】www.biopioneer.com.tw

【原廠網址】www.biovision.com

 

 

 

DUB相關抑制劑/Spautin-1 貨號#2037-5

Spautin-1

An USP10 and USP13 inhibitor

Product Name: Spautin-1

Alternate Name/Synonyms: 6-Fluoro-N-(4-fluorobenzyl)quinozaline-4-amine

Description: Cell-permeable. A specific and potent
autophagy inhibitor in mammalian cells. It promotes the degradation of Vps34
PI3 kinase complexes by inhibiting two ubiquitin specific peptidases, USP10 and
USP13, that target the Beclin1 subunit of Vps34 complexes. Spautin-1 blocks the
prosurvival autophagy pathway in cancer cells.

Peptide Sequence: N/A

Appearance: White solid

Formulation: N/A

CAS Number: 1262888-28-7

Molecular Formula: C₁₅H₁₁F₂
N₃

Molecular Weight: 271.26

Purity: ≥97% by HPLC

Solubility: DMSO (~ 100 mM)

Storage Temp.: -20°C

Shipping Conditions: Gel pack

Handling: Protect from air and light

 

--其它DUB抑制劑--

RP-619  貨號#2302-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1162&prev=1163&next=1156

LDN-57444 貨號#2016-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1163&prev=1164&next=1162
 

P22077 貨號#2301-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1164&prev=1165&next=1163

IU-1 貨號#2301-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1166&prev=1167&next=1165

WP-1130 貨號#2014-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1167&prev=1168&next=1166

Spautin-1 貨號#2037-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1168&prev=-1&next=1167

DUB相關抑制劑

 

RELATED PRODUCTS:

LDN-57444 (Cat. No. 2016-5, 25)

Spautin-1 (Cat. No. 2037-5, 25)

USP14 Inhibitor, IU-1 (Cat. No. 1845-5, 25)

USP7/USP47 Inhibitor P22077 (Cat. No. 2301-5, 25)

WP-1130 (Cat. No. 2014-5, 25)

 

 

【連絡人】許虹宜 0920-312382 Hung-Yi Hsu

【E-mail】taiding.biotech@msa.hinet.net

【公司電話】02-86609496【公司傳真】02-86609342

【相關網址】www.biovision.com

【公司網址】www.biopioneer.com.tw

 

 

 

DUB相關抑制劑/WP-1130 貨號#2014-5

WP-1130

A selective DUB (deubiquitinases) inhibitor

WP1130 (degrasyn) is a selective deubiquitinase
(DUB) inhibitor and also inhibits Bcr/Abl with IC50 of 1.8 μM.

Product Name: WP-1130

Alternate Name/Synonyms: (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide;
Degrasyn

Description: Cell-permeable. WP1130 acts as a
partly selective DUB (deubiquitinases) inhibitor, directly inhibiting DUB
activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival
protein stability and 26S proteasome function. WP1130-mediated inhibition of
tumor-activated DUBs results in downregulation of antiapoptotic and
upregulation of proapoptotic proteins, such as MCL-1 and p53. Blocks JAK2
signaling via JAK2 ubiquitination.

Peptide Sequence: N/A

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 856243-80-6

Molecular Formula: C₁₉H₁₈BrN₃O

Molecular Weight: 384.27

Purity: ≥98% by TLC

Solubility: DMSO (40 mg/ml) or EtOH (25 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: Gel pack

Handling: Protect from air and light

 

--其它DUB抑制劑--

RP-619  貨號#2302-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1162&prev=1163&next=1156

LDN-57444 貨號#2016-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1163&prev=1164&next=1162
 

P22077 貨號#2301-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1164&prev=1165&next=1163

IU-1 貨號#2301-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1166&prev=1167&next=1165

WP-1130 貨號#2014-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1167&prev=1168&next=1166

Spautin-1 貨號#2037-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1168&prev=-1&next=1167

DUB相關抑制劑

 

RELATED PRODUCTS:

LDN-57444 (Cat. No. 2016-5, 25)

Spautin-1 (Cat. No. 2037-5, 25)

USP14 Inhibitor, IU-1 (Cat. No. 1845-5, 25)

USP7/USP47 Inhibitor P22077 (Cat. No. 2301-5, 25)

WP-1130 (Cat. No. 2014-5, 25)

 

 

【連絡人】許虹宜 0920-312382 Hung-Yi Hsu

【E-mail】taiding.biotech@msa.hinet.net

【公司電話】02-86609496【公司傳真】02-86609342

【相關網址】www.biovision.com

【公司網址】www.biopioneer.com.tw

 

DUB相關抑制劑/IU-1 貨號#2301-5

USP14
Inhibitor, IU1

A USP14 inhibitor

IU1是一種細胞滲透性的,可逆的proteasome（蛋白酶）選擇性抑制劑，作用於USP14 時，IC50為4.7 μ M，比作用於IsoT 選擇性高25倍。

Alternate
Name/Synonyms: 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)-ethanone

Appearance:
White
to off-white solid

CAS
Number:  314245-33-5

Molecular
Formula:  C₁₈H₂₁FN₂O

Molecular
Weight: 300.37

Purity:
≥98%
by HPLC

Solubility:
DMSO
(20 mg/ml)

Storage
Temp.: -20°C

Shipping
Conditions: gel pack

Description:
A
cell-permeable, reversible and selective inhibitor of the deubiquitinating
activity of human USP14 (IC₅₀ = 4-5 µM). IU1 promotes
cell survival during proteotoxic stress and selectively stimulates
ubiquitin-dependent protein degradation in vitro at 34 μM. 

Handling:
Protect
from air and light

 

 

--其它DUB抑制劑--

RP-619  貨號#2302-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1162&prev=1163&next=1156

LDN-57444 貨號#2016-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1163&prev=1164&next=1162
 

P22077 貨號#2301-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1164&prev=1165&next=1163

IU-1 貨號#2301-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1166&prev=1167&next=1165

WP-1130 貨號#2014-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1167&prev=1168&next=1166

Spautin-1 貨號#2037-5

http://tw.myblog.yahoo.com/taiding2000/article?mid=1168&prev=-1&next=1167

DUB相關抑制劑

 

RELATED PRODUCTS:

LDN-57444 (Cat. No. 2016-5, 25)

Spautin-1 (Cat. No. 2037-5, 25)

USP14 Inhibitor, IU-1 (Cat. No. 1845-5, 25)

USP7/USP47 Inhibitor P22077 (Cat. No. 2301-5, 25)

WP-1130 (Cat. No. 2014-5, 25)

 

 

【連絡人】許虹宜 0920-312382 Hung-Yi Hsu

【E-mail】taiding.biotech@msa.hinet.net

【公司電話】02-86609496【公司傳真】02-86609342

【相關網址】www.biovision.com

【公司網址】www.biopioneer.com.tw