DUB相關抑制劑/IU-1 貨號#2301-5





USP14
Inhibitor, IU1


A USP14 inhibitor





IU1是一種細胞滲透性的,可逆的proteasome(蛋白酶)選擇性抑制劑,作用於USP14 時,IC504.7 μ M,比作用於IsoT 選擇性高25倍。





Alternate
Name/Synonyms:
1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)-ethanone





Appearance:
White
to off-white solid





CAS
Number: 
314245-33-5





Molecular
Formula: 
C₁₈H₂₁FNO





Molecular
Weight:
300.37





Purity:
≥98%
by HPLC





Solubility:
DMSO
(20 mg/ml)





Storage
Temp.:
-20°C





Shipping
Conditions:
gel pack





Description:
A
cell-permeable, reversible and selective inhibitor of the deubiquitinating
activity of human USP14 (IC
₅₀ = 4-5 µM). IU1 promotes
cell survival during proteotoxic stress and selectively stimulates
ubiquitin-dependent protein degradation in vitro at 34 μM. 





Handling:
Protect
from air and light





【連絡人】許虹宜 0920-312382 Hung-Yi Hsu





E-mailtaiding.biotech@msa.hinet.net





【公司電話】02-86609496【公司傳真】02-86609342





【相關網址】www.biovision.com





【公司網址】www.biopioneer.com.tw





 


 

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