【DUB相關抑制劑/IU-1】Biovision 貨號#2301-5。細胞滲透性的,可逆的proteasome選擇性抑制劑，作用於USP14 時，比作用於IsoT 選擇性高25倍。－太鼎生物科技/太鼎食安科技

DUB相關抑制劑/IU-1 貨號#2301-5

USP14
Inhibitor, IU1

A USP14 inhibitor

IU1是一種細胞滲透性的,可逆的proteasome（蛋白酶）選擇性抑制劑，作用於USP14 時，IC50為4.7 μ M，比作用於IsoT 選擇性高25倍。

Alternate
Name/Synonyms: 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)-ethanone

Appearance:
White
to off-white solid

CAS
Number: 314245-33-5

Molecular
Formula: C₁₈H₂₁FN₂O

Molecular
Weight: 300.37

Purity:
≥98%
by HPLC

Solubility:
DMSO
(20 mg/ml)

Storage
Temp.: -20°C

Shipping
Conditions: gel pack

Description:
A
cell-permeable, reversible and selective inhibitor of the deubiquitinating
activity of human USP14 (IC₅₀ = 4-5 µM). IU1 promotes
cell survival during proteotoxic stress and selectively stimulates
ubiquitin-dependent protein degradation in vitro at 34 μM.

Handling:
Protect
from air and light

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