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詳細產品資訊，請登錄www.trevigen.com 查詢，或與太鼎生物科技有限公司(02)86609496聯繫(台灣區總代理商)
更多參考內容:
WWW.BIOPIONEER.COM.TW
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April 2011
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A Complete Portfolio of PARP Kits.
Due to the complexity of monitoring DNA damage and the multiple applications for measuring PARP or PARP activity, Trevigen has developed a portfolio of PARP kits for use in research applications.
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PARP in vivo Pharmacodynamic Assay II
accurately measures net PAR levels in cellular extracts and has been used to document differences in PAR levels in human tumor lysates from a variety of tissues, organs, and xenografts with a sensitivity of 2 pg/ml.
PARP catalyzes the NAD-dependent addition of poly (ADP-ribose) (PAR) onto itself and adjacent nuclear proteins. PARP-1 is regarded as a promising target for the development of drugs useful in various regimens of cancer therapy, inflammation, ischemia and neurodegeneration. More recently the discovery that breast cancers deficient in homologous recombination are sensitive to nontoxic PARP inhibitors has resulted in efforts by numerous pharmaceutical companies to develop PARP-1 specific drugs.
Trevigen's PARP in vivo Pharmacodynamic Assay uses a validated sample processing regimen and a chemiluminescent, plate-based (96 wells) sandwich ELISA format that accurately reports PAR levels in lysates with a sensitivity of 2 pg/ml and a linear dynamic range to 1,000 pg/ml.
Applications
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Quantification of PAR in peripheral blood mononuclear cells, tissue culture cells, and tumor lysates from various tissues, organs and xenografts.
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Monitoring the efficacy of PARP inhibitors on cellular PAR formation.
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Verifying observations of enhanced cancer cell cytotoxicity arising from PARP inhibitor/anticancer drug combination therapy.
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Description
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Size
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Cat. #
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HT PARP in vivo Pharmacodynamic Assay II
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96 Samples
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4520-096-K
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Trevigen products include over 500 kits and reagents in the areas of DNA damage, apoptosis, oxidative stress, and cancer cell behavior. I invite you to visit our website at www.trevigen.com for additional product information or contact your local distributor. Trevigen products are available
through VWR and Thermo Fisher Scientific.
TREVIGEN INC. :: 8405 HELGERMAN CT. :: GAITHERSBURG, MD 20877
1.800.TREVIGEN :: 1.800.873.8443 :: (FAX) 1.301.560.4973 :: INFO@TREVIGEN.COM
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