【H7N9 NA蛋白質】#40109-V07H。H7N9 (A/Shanghai/1/2013) NA / Neuraminidase Protein－太鼎生物科技/太鼎食安科技

H7N9 NA蛋白質

Influenza A H7N9
(A/Shanghai/1/2013) NA / Neuraminidase Protein

H7N9
(A/Shanghai/1/2013) NA / Neuraminidase Protein Product Information

Synonym :	NA
Protein Construction:	A DNA sequence encoding the Influenza A virus (A/Shanghai/1/2013(H7N9)) neuraminidase (His36-Leu465) was expressed with an N-terminal polyhistidine tag.
Source:	Influenza A virus
Expression Host:	Human Cells

H7N9
(A/Shanghai/1/2013) NA / Neuraminidase Protein
QC Testing

Purity:	> 95 % as determined by SDS-PAGE	SDS-PAGE: H7N9 NA protein
Endotoxin:	< 1.0 EU per μg of the protein as determined by the LAL method
Stability:	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal:	His
Molecular Mass:	The recombinant neuraminidase of Influenza A virus (A/Shanghai/1/2013(H7N9)) comprises 448 amino acids and has a predicted molecular mass of 50.6 kDa. The apparent molecular mass of the protein is approximately 61-69 kDa in SDS-PAGE under reducing conditions.
Formulation:	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

H7N9
(A/Shanghai/1/2013) NA / Neuraminidase Amino Acid Sequence

HHHHHHHHHH LEVLFQGPHL KPSCNCSHSQ PETTNTSQTI INNYYNETNI
TNIQMEERTS RNFNNLTKGL CTINSWHIYG KDNAVRIGES SDVLVTREPY VSCDPDECRF YALSQGTTIR
GKHSNGTIHD RSQYRALISW PLSSPPTVYN SRVECIGWSS TSCHDGKSRM SICISGPNNN ASAVVWYNRR
PVAEINTWAR NILRTQESEC VCHNGVCPVV FTDGSATGPA DTRIYYFKEG KILKWESLTG TAKHIEECSC
YGERTGITCT CKDNWQGSNR PVIQIDPVAM THTSQYICSP VLTDNPRPND PNIGKCNDPY PGNNNNGVKG
FSYLDGANTW LGRTISTASR SGYEMLKVPN ALTDDRSKPI QGQTIVLNAD WSGYSGSFMD YWAEGDCYRA
CFYVELIRGR PKEDKVWWTS NSIVSMCSST EFLGQWNWPD GAKIEYFL

H7N9
(A/Shanghai/1/2013) NA / Neuraminidase Protein Usage Guide

Storage:	Store it under sterile conditions at -70℃ . It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

H7N9
(A/Shanghai/1/2013) NA / Neuraminidase Protein Related Products & Topics

H7N9

(A/Shanghai/1/2013) NA / Neuraminidase Protein Description

H7N9 is a subtype of nfluenza virus A. On April 1, 2013, the World Health Organization (WHO) first
reported 3 human infections with a new influenza A (H7N9) virus in China . Since
then, additional cases have been reported. This new H7N9 virus is an avian
(bird) influenza (flu) virus. Influenza (flu) is a respiratory infection in
mammals and birds. The virus is divided into three main types (Influenza A,
Influenza B, and Influenza C), which are distinguished by differences in two
major internal proteins (hemagglutinin (HA) and neuraminidase (NA)). The
influenza viral neuraminidase (NA) protein is a tetramer with an enzyme active
site on the head of each monomer. Subtypes are further divided into strains;
each genetically distinct virus isolate is usually considered to be a separate
strain. NA protein is a second major surface antigen of the virion.
Neuraminidase (NA) cleaves terminal sialic acid from glycoproteins or
glycolipids. Thus, it functions to free virus particles from host cell
receptors, to permit progeny virions to escape from the cell in which they
arose, and so facilitate virus spread.

References

1. Suzuki T. et al., 2005, J Virol. 79: 11705-15.

2. Shinya K. et al., 2006, Nature. 440 (7083): 435-6.

3. Von Itzstein M. 2007, Nat Rev Drug Discov. 6: 967-74.

4. Christophe F. et al., 2009, Science. 324: 1557-61.

5. Marjuki H. et al., 2006, J Biol Chem. 281: 16707-15.

6. Christophe F. et al., 2009, Science. 324:1557-61