【Galectin-3重組蛋白】 Prospec 重組蛋白。貨號CYT-606 LGALS1、LGALS2、LGALS3、LGALS4、LGALS7、LGALS8、LGALS9－太鼎生物科技/太鼎食安科技

* --Galectin-3 重組蛋白---貨號CYT-606

Galectin-3，為分子量31 kDa的蛋白質，是屬於beta-galectose-binding lectin家族的一員，能正向與負向地調節T細胞和巨噬細胞的免疫功能。Galectin-3主要分布於細胞質內，然而近期研究也在細胞核、細胞表面以及細胞外間質偵測到Galectin-3的表現。

相同字義: Galectin-3, GAL3, MAC2, CBP35, GALB, GALIG, LGALS2, LGALS3,
Galactose-specific lectin 3, Mac-2 antigen, IgE-binding protein, 35 kDa lectin,
Carbohydrate-binding protein 35, CBP 35, Laminin-binding protein, Lectin L-29,
L-31, Galactoside-binding protein, GALBP.

Galectin-3---(Gal3)---功能介紹

Galectin-3 mediates with the alpha-3, beta-1
integrin the stimulation by cspg4 of endothelial cells migration. Galectin-3
plays an necessary part during the acquisition of vasculogenic mimicry and
angiogenic properties associated with melanoma progression. LGALS3
overexpression is highly expressed in early stages of papillary carcinoma, and
its expression intensity declines during tumor progression. Serum levels of
LGALS3 are high in patients with thyroid malignancy but there is considerable
overlap in serum LGALS3 concentrations between those with benign and malignant
nodular thyroid disease. LGLAS3 takes part as an immune regulator to inhibit
T-cell immune responses and promote tumor growth, as a result providing a new
mechanism for tumor immune tolerance.

Galectin3---(Gal3)---重組蛋白描述

Description	LGALS3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 250 amino acids and having a molecular mass of 26 kDa. The LGALS3 is purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation	The Galectin-3 protein was lyophilized from a concentrated (1mg/ml) containing 10mM sodium phosphate buffer, pH-7.5 and 50mM NaCl.
Solubility	It is recommended to reconstitute the lyophilized LGALS3 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability	Lyophilized Galectin-3 Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Galectin-3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Purity	Greater than 97.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Amino acid sequence	ADNFSLHDAL SGSGNPNPQG WPGAWGNQPA GAGGYPGASY PGAYPGQAPP GAYPGQAPPG AYHGAPGAYP GAPAPGVYPG PPSGPGAYPS SGQPSAPGAY PATGPYGAPA GPLIVPYNLP LPGGVVPRML ITILGTVKPN ANRIALDFQR GNDVAFHFNP RFNENNRRVI VCNTKLDNNW GREERQSVFP FESGKPFKIQ VLVEPDHFKV AVNDAHLLQY NHRVKKLNEI SKLGISGDID LTSASYTMI.
Biological Activity	Determined by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2µg/ml with a peak response obtained at 220,000ng/ml corresponding to a specific activity of 5IU/mg.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.