太鼎生物科技/太鼎食安科技

DESCRIPTION

Clone
581 (Class III)

Ig
Isotype Mouse IgG1

Specificity
Human CD34 Class III epitope

CD34 is a 110-120 kDa heavily
O-glycosylated type I transmembrane glycoprotein. It is expressed on a small
subpopulation (2-4%) of bone marrow cells including hematopoietic stem cells,
small vessel endothelial cells and tumors of epithelial origin, and a subset of
fibroblasts. It is believed that hematopoietc CD34 plays a role in modulating
adhesion and as well as signal transduction through its phosphorylation by
activated protein kinase C. The monoclonal antibody 581 reacts to the class III
CD34 epitope which is resistant to neuraminidase, chymopapain and
glycoprotease.1-8

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