DNA修復基因沉默細胞株(Knockdown cell lines)，全新上市。
在BER路徑中，提供20種以上基因沉默細胞株。包括鹼基切除修復（BER）的途徑、錯配修復（MMR），和非同源末端連接（NHEJ）。特定shRNA慢病毒轉導之LN428膠質母細胞瘤，經由RT-PCR其基因沉默效能為63%~98%。其無特定病毒之污染，品質保證。
DNA repair proteins maintain the stability of the genome. When repair protein function is impaired through mutations, the genome may become unstable which is a hallmark of solid tumors. The availability of this panel of knockdown cell lines will permit scientists to study the molecular etiology of tumor genomic instability and to exploit it in oncology research. The Knockdown line encompasses the Base Excision Repair pathway, Non Homologous End Joining, and Mismatch Repair pathways. Trevigen’s Knockdown Cell Lines are target specific LN428 (glioblastoma) shRNA lentivirus transduced cells. They are rigorously qualified and mycoplasma free. The percent knockdown levels range from 63-98% as evaluated by RT-PCR. Lentiviruses are maintained by puromycin selection. *Cell lines are provided under an MTA.Tools to Study Genomic Instability and Genotoxic Stress
DNA Repair Gene Knockdown Cell Lines*
FEATURES:ORDERING INFORMATION:
Mismatch Repair
Catalog # Product Name # of Cells Per Vial Size %KD by RT-PCR 55027-001-01 PMS2 Knock Down Cell Line (MTA Required prior to shipment) 1x106 1 vial 84% 55028-001-01 MLH3 Knock Down Cell Line (MTA required before shipment) 1x106 1 vial 71% 55021-001-01 MSH3 Knock Down Cell Line (MTA required before shipment) 1x106 1 vial 83% 55034-001-01 XRCC6 (Ku70) Knock Down Cell Line (MTA required before shipment) 1x106 1 vial 92% 55026-001-01 MLH1 Knock Down Cell Lines (MTA required to shipment) 1x106 1 vial 80% 55024-001-01 MSH5 Knock Down Cell Line (MTA required to shipment) 1x106 1 vial 92% 55035-001-01 XRCC5 (Ku80) Knock Down Cell Line (MTA required before shipment) 1x106 1 vial 85% 55022-001-01 MSH6 Knock Down Cell Line (MTA required to shipment) 1x106 1 vial 93%
Non-Homologous End Joining
Catalog # Product Name # of Cells Per Vial Size %KD by RT-PCR 55037-001-01 SIRTI Knock Down Cell Line (MTA required prior to shipment) 1x106 1 vial 95% 55036-001-01 PRKDC Knock Down Cell Line (MTA required prior to shipping) 1x106 1 vial 94% 55038-001-01 SIRTI2 Knock Down Cell Line (MTA required prior to shipping) 1x106 1 vial 98%
Knockdown Control
Catalog # Product Name # of Cells Per Vial Size %KD by RT-PCR 5503-001-01 Knock Down Control Cell Line (MTA Required prior to shipment) 1x106 1 vial N/A 
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