太鼎生物科技/太鼎食安科技

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JC-1 ( 5, 5’ ,6, 6’ -tetrachloro-1, 1’ ,3, 3’ -tetraethyl-benzimidazolylcarbocyanine Iodide_
Catalog#: 1130-5  | Size: 5 mg

JC-1 染劑是一種粒線體染劑(mitochondrial dye)。JC-1染劑可以測量粒線體膜電位，染出粒線體膜電位失衡現象。其原理為: 當帶正電的JC-1染劑進入細胞中，會被粒線體膜上的負性電場所吸引並聚集形成二聚體，在螢光顯微鏡下發出橘組色螢光；若是粒線體上膜電位消失，使JC-1染劑無法被膜上電場所吸引，而散佈在細胞中，並呈現單體狀態，在螢光顯微鏡下發出綠色螢光。JC-1染劑可以用來觀察細胞凋亡現象，在健康的細胞中，發出紅色螢光；當細胞胞凋亡發生時，發出綠色染光。

Description: JC-1 is a mitochondrial dye that stains mitochondria in living cells in a membrane potential-dependent fashion. JC-1 monomer is in equilibrium with so called J-aggregates, which are favored at higher mitochondrial membrane potential. The monomer JC-1 has green fluorescence (lem = 527 nm), while the J-aggregates have red fluorescence (lem = 590 nm). Therefore, it has been possible to use fluorescence ratioing technique to study mitochondrial membrane potential. JC-1 is particularly useful for apoptosis studies. In apoptotic cells, the dye stays in the cytoplasm and fluoresces green, while in healthy cells, the dye aggregates in the mitochondria and fluoresces red.

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