連接蛋白(Connexins)或間隙連接(gap junctions)是結構相關的跨膜蛋白(structurally-related transmembrane proteins)家族。間隙連接(Gap junctions)包含允許離子和小分子在相鄰細胞之間通過的通道。這種細胞間通訊(intercellular communication)與細胞對細胞內信號分子的反應的協調有關。鈣(Calcium)和肌醇磷酸鹽(inositol phosphates)是可以通過間隙連接通道的第二信使。這種合成的連接蛋白－太鼎生物科技/太鼎食安科技

雷帕黴菌（Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | G-418 (80 S 核醣體延伸抑制劑)

細胞反應(Cellular responses)由與特定受體結合的蛋白質(proteins)、藥物(drugs)或病原體(pathogens)觸發。受體介導(Receptor mediated signaling)的信號傳導是放大信號的酶促反應級聯。調節受體功能的激動劑(agonists)和拮抗劑(antagonists)是研究和醫療實踐的重要工具。

Gap 27 | CAS#198284-64-9 APExBIO 貨號A1045

APExBIO盒子樣品1-300x246.jpg

Selective gap junction blocker.

連接蛋白(Connexins)或間隙連接(gap junctions)是結構相關的跨膜蛋白(structurally-related transmembrane proteins)家族。間隙連接(Gap junctions)包含允許離子和小分子在相鄰細胞之間通過的通道。這種細胞間通訊(intercellular communication)與細胞對細胞內信號分子的反應的協調有關。鈣(Calcium)和肌醇磷酸鹽(inositol phosphates)是可以通過間隙連接通道的第二信使。這種合成的連接蛋白模擬肽(connexin-mimetic peptide) Gap 27 用於評估間隙連接通訊(gap-junctional communication)對破骨細胞(osteoclastic bone)骨吸收(bone resorption)的貢獻。得出的結論是，間隙連接通訊對於適當的骨重塑(bone remodeling)是必要的。

1. Fan J, Chen Y, et al. "Multi-walled carbon nanotubes induce IL-1β secretion by activating hemichannels-mediated ATP release in THP-1 macrophages." Nanotoxicology. 2020;1-18. PMID:32538272

2. Ni X, Li XZ, et al. "Increased expression and functionality of the gap junction in peripheral blood lymphocytes is associated with hypertension-mediated inflammation in spontaneously hypertensive rats." Cell Mol Biol Lett. 2018 Aug 20;23:40. PMID:30151015

3. HAI-CHAO ZHANG, ZHONG-SHUANG ZHANG, et al."Connexin 43 in splenic lymphocytes is involved in the regulation of CD4+ CD25+ T lymphocyte proliferation and cytokine production in hypertensive inflammation." INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2017 October 20.

4. Ni X, Wang A, et al. "Up-regulation of gap junction in peripheral blood T lymphocytes contributes to the inflammatory response in essential hypertension." PLoS One. 2017 Sep 14;12(9):e0184773. PMID:28910394

5. Koenen, Anna, et al. "Effects of renal denervation on renal pelvic contractions and connexin expression in rats." Acta Physiologica (2015). PMID:26436542

Physical Appearance	A solid
Storage	Desiccate at -20°C
M.Wt	1304.55
Cas No.	198284-64-9
Formula	C₆₀H₁₀₁N₁₅O₁₇
Synonyms	Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile
Solubility	insoluble in EtOH; ≥5 mg/mL in H2O; ≥65.25 mg/mL in DMSO
Chemical Name	Gap 27
SDF	Download SDF
Canonical SMILES	CCC(C)C(C(=O)NC(C(C)CC)C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(C(C)CC)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)O)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C(CO)N
Shipping Condition	Ship with blue ice, or upon other requests.
General tips	For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

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APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域，還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。