雷帕黴菌(Rapamycin)| Romidepsin (FK228, depsipeptide) | Daptomycin | G-418 (80 S 核醣體延伸抑制劑)
Laminin (925-933) | 層粘連蛋白 (925-933)CAS#110590-60-8 APExBIO 貨號A1023
細胞反應(Cellular responses)由與特定受體結合的蛋白質(proteins)、藥物(drugs)或病原體(pathogens)觸發。受體介導(Receptor mediated signaling)的信號傳導是放大信號的酶促反應級聯。調節受體功能的激動劑(agonists)和拮抗劑(antagonists)是研究和醫療實踐的重要工具。
Extracellular matrix glycoprotein
Laminin層粘連蛋白 (925-933) 是一種肽 (Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg),來源於與層粘連蛋白受體結合(laminin receptor)的層粘連蛋白 B1 鏈的殘基 925-933。Laminin層粘連蛋白 (925-933)是細胞外基質糖蛋白家族(extracellular matrix glycoproteins),是基底膜(basement membranes)的主要非膠原成分。它們涉及多種生物學過程,包括細胞粘附(cell adhesion)、分化(differentiation)、遷移(migration)、信號傳導(signaling)、神經突生長(neurite outgrowth)和轉移(metastasis)。層粘連蛋白由 3 條不同的鏈組成:層粘連蛋白 α、β 和 γ(分別為 A、B1 和 B2)層粘連蛋白 β 1 鏈具有 7 個結構不同的結構域,與其他 β 鏈異構體共享這些結構域。Laminin層粘連蛋白 (925-933),β1 在大多數產生基底膜(basement membranes)的組織中表達,並且是構成層粘連蛋白 1 的 3 條鏈之一,層粘連蛋白 1 是從 Engelbreth-Holm-Swarm (Engelbreth-Holm-Swarm , EHS) 腫瘤中分離的第一個層粘連蛋白。確定了參與細胞附著(cell attachment)、趨化性(chemotaxis)和與層粘連蛋白受體結合的 β 1 鏈中的一個序列,並顯示其具有抑制轉移(metastasis)的能力。.
- Talbert, Lance Edward. "Advancing Academics Through Laboratory and Classroom Research: Probing Biomolecular Structure with Novel Mass Spectrometry Methods and Revisiting Student Learning Tools." UNIVERSITY OF CALIFORNIA. June 2019.
- Lance E.Talbert, XingZhang, et al. "Synthesis of New S-S and C-C Bonds by Photoinitiated Radical Recombination Reactions in the Gas Phase." International Journal of Mass Spectrometry. Available online 5 April 2019.
- Talbert LE, Julian RR. "Directed-Backbone Dissociation Following Bond-Specific Carbon-Sulfur UVPD at 213 nm." J Am Soc Mass Spectrom. 2018 Apr 5.PMID:29623659
Physical Appearance |
A solid |
Storage |
Store at -20°C |
M.Wt |
967.06 |
Cas No. |
110590-60-8 |
Formula |
C40H62N12O14S |
Synonyms |
H2N-Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-OH |
Solubility |
≥15.53 mg/mL in H2O; ≥17.77 mg/mL in EtOH; ≥48.35 mg/mL in DMSO |
Chemical Name |
Laminin (925-933) |
SDF |
|
Canonical SMILES |
CCC(C)C(C(=O)NCC(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)O)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)CNC(=O)C2CCCN2C(=O)C(CC(=O)O)NC(=O)C(CS)N |
Shipping Condition |
Ship with blue ice, or upon other requests. |
General tips |
For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon. |
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