太鼎生物科技/太鼎食安科技

HSPG2 antibody

Heparan Sulfate Proteoglycan 2 (HSPG2).

Perlecan is a large multidomain
proteoglycan that binds to and cross-links many extracellular matrix (ECM)
components and cell-surface molecules.Perlecan is synthesized by both vascular
endothelial and smooth muscle cells and deposited in the extracellular matrix. Perlecan
is highly conserved across species and the available data indicate that it has
evolved from ancient ancestors by gene duplication and exon shuffling.Perlecan
is a key component of the vascular extracellular matrix, here it interacts with
a variety of other matrix components and helps to maintain the endothelial
barrier function. Perlecan is a potent inhibitor of smooth muscle cell
proliferation and is thus thought to help maintain vascular homeostasis.
Perlecan can also promote growth factor activity and thus stimulate endothelial
growth and re-generation.

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