【Caspase 活性分析套組】Biovisoin提供一系列細胞凋亡Caspase活性分析套組，產品種類包括Caspase1、2、3、4、5、6、7、8、9、10、11、12、13活性分析套組。－太鼎生物科技/太鼎食安科技

Caspase 活性分析套組

Caspases

【Caspase 活性分析套組】Biovisoin提供一系列細胞凋亡Caspase活性分析套組，產品種類包括Caspase1、2、3、4、5、6、7、8、9、10、11、12、13活性分析套組。

Caspases are responsible for the deliberate
disassembly of the cell into apoptotic bodies during apoptosis.
Caspases are present as inactive pro-enzymes that are activated by proteolytic
cleavage. Caspases 8, 9, 12 and 3 are situated at pivotal junctions in
apoptosis pathways. Caspase 8 initiates disassembly in response to
extracellular apoptosis-inducing ligands and is activated in a complex
associated with the cytoplasmic death domain of many cell surface receptors for
the ligands. Caspase 9 activates disassembly in response to agents or insults
that trigger the release of cytochrome c from mitochondria and is activated
when complexed with apoptotic protease activating factor 1 (APAF-1) and
extra-mitochondrial cytochrome c. Caspase-12 appears to be activated by ER
stress. All three caspase pathways lead to caspase-3 activation. Caspase 3
amplifies caspase 8, caspase 9, and caspase-12 initiation signals into
full-fledged commitment to disassembly. Caspase 8 and caspase 9 activate
caspase 3 by proteolytic cleavage and caspase 3 then cleaves vital cellular
proteins or other caspases