2-NBDG | glucose uptake攝取分析 CAS#186689-07-6 APExBIO 貨號B6035－太鼎生物科技/太鼎食安科技

雷帕黴菌（Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | G-418 (80 S 核醣體延伸抑制劑)

2-NBDG | CAS#186689-07-6 APExBIO 貨號B6035

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fluorescent glucose analog for visualizing glucose uptake into living cells.

2-NBDG 是一種螢光標記的 2-脫氧葡萄醣(2-deoxy-glucose)類似物(analog)，可用作評估細胞葡萄糖代謝(cellular glucose metabolism)的示蹤劑(tracer)。葡萄糖(Glucose)是維持組織中細胞活動(cell activities)和恆定狀態(homeostasis)的必要能量來源。糖代謝(Glucose metabolism)是許多疾病的重要靶標，並隨著病理狀況(pathological condition)而變化，因此，對糖代謝(glucose metabolism)的評估可以成為疾病進展的重要指標。

2-NBDG可用於多種體外細胞 (10uM)，如HepG2人肝癌細胞(HepG2 human hepatocarcinoma cells)、L6大鼠骨骼肌細胞(L6 rat skeletal muscle cells)、MCF-7乳腺癌上皮細胞(MCF-7 breast cancer epithelial cells)和星形膠質細胞(astrocytes)，也用於疾病模型(disease models)、癲癇大鼠(epilepsy rat)、高血糖(hyperglycemia)、糖尿病(diabetes)或小鼠癌症異種移植模型(mouse xenograft model of cancer)。

2-NBDG 通過葡萄糖轉運(glucose transporters)蛋白進入細胞，隨後被己糖激酶(hexokinase)磷酸化(phosphorylated)並被困在細胞內。可以對細胞產生的螢光進行流式細胞術檢測(Flow cytometric detection)，以檢查活細胞對 2-NBDG 的攝取(2-NBDG uptake)，並可以使用螢光微孔板測定法(fluorescence microplate assay)測量轉運的 2-NBDG 的細胞內濃度。它也可以簡單地用螢光成像顯微鏡(fluorescence imaging microscopy)或 CCD 相機檢測。

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Product Citation

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	342.26
Cas No.	186689-07-6
Formula	C₁₂H₁₄N₄O₈
Solubility	insoluble in DMSO; ≥17.1 mg/mL in H2O with ultrasonic; ≥2.93 mg/mL in EtOH with gentle warming and ultrasonic
Chemical Name	(3R,4R,5S,6R)-6-(hydroxymethyl)-3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)tetrahydro-2H-pyran-2,4,5-triol
SDF	Download SDF
Canonical SMILES	OC[C@](O1)([H])[C@](O)([H])[C@@](O)([H])[C@](NC2=CC=C(N(=O)=O)C3=NON=C23)([H])C1([H])O
Shipping Condition	Ship with blue ice, or upon other requests.
General tips	For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

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APExBIO提供優質的勝肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域，還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。

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