Salermide
Catalog#: 1873-5 | Size: 5 mg

Salermide,為SIRT1及SIRT2抑制者。在NAD+-dependent histone deacetylases 扮演基因調控之角色。引發腫瘤專一性凋亡細胞死亡。

The sirtuins (SIRTs) are a family of NAD⁺-dependent histone deacetylases involved in gene regulation. Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~ 20 µM) by reactivating proapototic genes that are repressed by SIRT1. Salermide is a stronger Sirtuin inhibitor than sirtinol.

Alternate Name/Synonyms: N-​[3-​[[(2-​hydroxy-​1-​naphthalenyl)methylene]amino]phenyl]-​a-​methyl-​benzeneacetamide

Peptide Sequence: N/A

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1105698-15-4

Molecular Formula: C₂₆H₂₂N₂O₂

Molecular Weight: 394.47

Purity: ≥98

Solubility: DMSO ( 100 mM )

Storage Temp.: -20°C

Shipping Conditions: gel pack

Description: Cell-permeable. Salermide is an inhibitor of SIRT1 and SIRT2. In vitro, Salermide has a stronger inhibitory effect on SIRT2 than on SIRT1. It induces massive apoptosis in tumor cells through reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by SIRT1

Handling: Protect from air and moisture