太鼎生物科技/太鼎食安科技

 雷帕黴菌（Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | G-418 (80 S 核醣體延伸抑制劑) 

雷帕黴菌（Rapamycin） | CAS#53123-88-9 APExBIO貨號A8167

Original antifungal antibiotic

雷帕黴菌（Rapamycin）作為一種原始的抗真菌抗生素，由吸水鏈黴菌(Streptomyces hygroscopicus)生產。由於其免疫抑制作用(immunosuppressive effect)，現已用於預防移植排斥反應。它還表現出對幾種可移植腫瘤(transplantable tumors)的活性和對白血病無活性(inactive against leukemias)具輕微活性。雷帕黴菌（Rapamycin）的免疫抑制作用是通過抑制T細胞的活化(activation)和增殖(proliferation)來發揮的。雷帕黴菌（Rapamycin）與 FK 結合蛋白 12 (FKBP12) 結合併形成雷帕黴素-FKBP12 複合物(rapamycin-FKBP12 complex)，該複合物調節一種在細胞週期(cell cycle)進程中起重要作用的酶。Rapamycin was used as a kind of original antifungal antibiotic, which is produced by Streptomyces hygroscopicus. Now it has been used in the prevention of transplant rejection because of its immunosuppressive effect.  It also exhibits activity against several transplantable tumors and slightly activity to inactive against leukemias. The immunosuppressive effect of Rapamycin is exerted by inhibiting the activation and proliferation of T cells. Rapamycin binds to FK-binding protein 12 (FKBP12) and forms the rapamycin-FKBP12 complex, which regulates an enzyme that plays an important role in the progression of the cell cycle.

• Purity = 98.00%
• COA (Certificate Of Analysis)
• MS (Mass Spectrometry)
• NMR (Nuclear Magnetic Resonance)
• MSDS (Material Safety Data Sheet)
• Datasheet

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