太鼎生物科技/太鼎食安科技

DUB相關抑制劑/ LDN-57444 貨號#2016-5

LDN-57444

A selective UCHL1 inhibitor

LDN-57444是可逆的DUB競爭性抑制劑，抑制UCch-L1時，IC50為0.88 μM,比作用於亞型 Uch-L3選擇性高30倍。

Product Name: LDN-57444

Alternate Name/Synonyms: 3-(O-acetyloxime),
5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione, C30, LDN 57444

Description: Cell-permeable. LDN-57444 is a potent,
reversible, competitive and active site-directed inhibitor of UCHL1 (Ki = 0.4
μM). Decreases proteasome activity and increases levels of ubiquitinated
proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein
distribution and spine morphology in vivo.

Peptide Sequence: N/A

Appearance: Yellow solid

Formulation: N/A

CAS Number: 668467-91-2

Molecular Formula: C₁₇H₁₁Cl₃N₂O₃

Molecular Weight: 397.64

Purity: ≥98% by TLC

Solubility: DMSO (20 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: Gel pack

Handling: Protect from air and light

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