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目前分類:【細胞凋亡/增殖/毒理分析套組】 (85)

瀏覽方式: 標題列表 簡短摘要

 





Propidium
Iodide





Propidium Iodide





Catalog#: 1056-1 | Size: 1 ml





Alternate Name/Synonyms: 3,8-Diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium
diiodide





Appearance: Liquid





Formulation: PBS ( 1 mg/ml)





CAS Number: 25535-16-4





Molecular Formula: C₂₇H₃₄IN





Molecular Weight: 668.39





Solubility: N/A





Storage Temp.: +4°C





Description: Propidium Iodide (PI) binds to
double-stranded DNA, but it can only cross the plasma membrane of nonviable
cells. When viewed using a fluorescence microscope with a rhodamine filter,
cells that have lost membrane integrity will show red PI staining throughout
the nuclei. For analysis by flow cytometry, the PI staining can be monitored in
FL2 channel.





【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜 0920-312382 taiding.biotech@msa.hinet.net





【臺北公司】02-86609496【傳真】02-86609342





【相關網址】www.biopioneer.com.tw




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Staurosporine





Staurosporine





Catalog#: 1048-01 | Size: 100 µg





Alternate
Name/Synonyms:
Antibiotic AM-2282





Appearance:
Pale
yellow solid





Formulation:
N/A





CAS
Number:
62996-74-1





Molecular
Formula:
C₂₈H₂₆NO





Molecular
Weight:
466.53





Purity:
>99%
by TLC





Solubility:
DMSO
( 5 mg/ml)





Storage
Temp.:
-20°C





Description:
Potent
inhibitor of protein kinase C and most other kinases, including tyrosine
kinases. Inhibits topoisomerase II directly by blocking transfer of
phosphodiester bonds from DNA to active site tyrosine. Induces apoptosis in CHO
cells at 1 µM.





【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜 0920-312382 taiding.biotech@msa.hinet.net





【臺北公司】02-86609496【傳真】02-86609342





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Annexin
V-Cy5 Reagent




----Annexin V 檢測試劑------

Annexin V是一種Ca+依賴的磷脂結磷脂結合蛋白(35-36 kDa),
對磷脂絲氨酸(phosphatidylserine ;PS)具高度親和性。當細胞進行細胞凋亡(apoptosis)時,細胞膜的PS會外翻到外膜。Biovision提供一系列Annexin V細胞凋亡染劑。Annexin-V結合FITCR-PEPE/Cy7、Cy3Cy7等不同波段染劑。直接應用於顯微鏡觀察及流氏細胞分析。





Annexin V-Cy5 Reagent


Catalog#: 1013-200 | Size: 200 assays





Product Highlights:

•Detection method- flow cytometry (Ex/Em = 649 /670 nm) using Helium-Neon Laser
and fluorescence microscopy

•Sample- Cell culture

•Simple, easy to use and convenient





Description: Annexin V-Cy5 is a bright fluorescent
reagent for detecting of the early stages of apoptosis. During apoptosis,
phosphatidylserine (PS) is translocated from the cytoplasmic face of the plasma
membrane to the cell surface. Annexin V has a strong, Ca²
-dependent affinity for PS and therefore serves as a
probe for detecting apoptosis. Cy5 fluorescent dye produces an intense signal
in the far-red region of the spectrum and therefore it is very useful for
multiple labeling of cells with green and red colored fluorescent probes. Cy5
yields fluorescence with a λmax emission of 670 nm.





Storage Temp.: +4°C





【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜 0920-312382 taiding.biotech@msa.hinet.net





【臺北公司】02-86609496【傳真】02-86609342





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Caspase-6
Inhibitor Z-VEID-FMK





Caspase-6 Inhibitor Z-VEID-FMK





Catalog#: 1011-100 | Size: 100 µl





Alternate Name/Synonyms: Z-VEID-FMK,
Caspase-6 Inhibitor (fluoromethylketone)





Peptide sequence: Z-Val-E(OMe)-Ile-Asp(OMe)-FMK





Appearance: Liquid





Formulation: In DMSO (2 mM)





CAS Number: N/A





Molecular Formula: C₃₁H₄₅FNO₁₀





Molecular Weight: 652.9





Purity: >98% by HPLC





Solubility: N/A





Storage Temp.: -20°C





Description: VEID is the specific recognition
sequence for caspase-6/Mch2. The inhibitor is designed as a methyl ester to
facilitate cell permeability. (CAUTION: If the intended use is on purified or
recombinant enzymes, esterase should be added to generate free carboxyl groups)
.





 





【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜 0920-312382 taiding.biotech@msa.hinet.net





【臺北公司】02-86609496【傳真】02-86609342





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Caspase-Family Inhibitor Z-VAD-FMK





Caspase-Family
Inhibitor Z-VAD-FMK





Catalog#: 1010-100 | Size: 100 µl





Alternate
Name/Synonyms:
Z-VAD-FMK, Caspase-Family Inhibitor (fluoromethylketone)





Peptide
sequence:
Z-Val-Ala-Asp(OMe)-FMK





Appearance:
Liquid





Formulation:
In
DMSO (2 mM)





CAS
Number:
187389-52-2





Molecular
Formula:
C₂₂H₃₀NOF





Molecular
Weight:
467.5





Purity:
Single
spot by TLC





Solubility:
N/A





Storage
Temp.:
-20°C





Shipping
Conditions:
gel pack





Description:
A
synthetic peptide that irreversibly inhibits activity of caspase family
proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to
facilitate cell permeability. The product can be used in both in vitro and in
vivo studies. The inhibitor is designed as a methyl ester to facilitate cell
permeability. (CAUTION: If the intended use is on purified or recombinant
enzymes, esterase should be added to generate free carboxyl groups).





Handling:
Protect
from light and moisture





【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜 0920-312382 taiding.biotech@msa.hinet.net





【臺北公司】02-86609496【傳真】02-86609342





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Caspase-3 Inhibitor Z-DEVD-FMK





Caspase-3
Inhibitor Z-DEVD-FMK





Catalog#: 1009-100 | Size: 100 µl





Alternate
Name/Synonyms:
Z-DEVD-FMK, Caspase-3 inhibitor (fluoromethylketone)





Peptide
sequence:
Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK





Appearance:
Liquid





Formulation:
In
DMSO (2 mM)





CAS
Number:
N/A





Molecular
Formula:
C₃₀H₄₁FNO₁₂





Molecular
Weight:
668.7





Purity:
>98%
by HPLC





Solubility:
N/A





Storage
Temp.:
-20°C





Shipping
Conditions:
gel pack





Description:
A
synthetic peptide inhibitor that irreversibly inhibits caspase-3 and related
protease/caspase activity and blocks apoptosis. DEVD is the specific
recognition sequence found in poly (ADP-ribose) polymerase (PARP). The
inhibitor is designed as a methyl ester to facilitate cell permeability.
(CAUTION: If the intended use is on purified or recombinant enzymes, esterase
should be added to generate free carboxyl groups).





Handling:
Protect
from light and moisture





【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜 0920-312382 taiding.biotech@msa.hinet.net





【臺北公司】02-86609496【傳真】02-86609342





【相關網址】www.biopioneer.com.tw




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Caspase-3
Substrate DEVD-AFC


 







Caspase-3 Substrate DEVD-AFC


Catalog#: 1007-1000 | Size: 1000 assays


Alternate Name/Synonyms: Ac-DEVD-AFC,
Caspase-3 Substrate Fluorogenic





Peptide sequence: Ac-Asp-Glu-Val-Asp-AFC





Appearance: Liquid





Formulation: In DMSO (1 mM)





CAS Number: N/A





Molecular Formula: C₃₀H₃₃FNO₁₃





Molecular Weight: 729





Purity: >98% by HPLC





Solubility: N/A





Storage Temp.: -20°C





Shipping Conditions: gel pack





Description: Ready-to-use fluorometric substrate
for caspase-3/CPP32 (Km = 9.7 µM) and related caspases that recognize the amino
acid sequence DEVD. The sequence DEVD is based on caspase-3 cleavage site in
poly (ADP-ribose) polymerase (PARP). CPP32 and related caspase activity can be
quantified by fluorescent detection of free AFC after cleaved from the peptide
substrate DEVD-AFC at Ex. = 400 nm and Em. = 505 nm, using a fluorometer or a
multi-well fluorescence plate reader. Alternatively, a shift in fluorescence
from blue to green upon cleavage can be visualized using a hand-held long-UV
lamp.





Handling: Potect from light and moisture






  • Ac-DEVD-AFC,
    Caspase-3
    螢光底物

  • Ac-DEVD-pNA,
    Caspase-3
    顯色底物

  • Ac-DEVD-pNA,
    Caspase-3
    顯色底物

  • Z-DEVD-FMK,
    Caspase-3
    抑制劑(氟甲基酮)

  • Z-DEVD-FMK,
    Caspase-3
    抑制劑(氟甲基酮)

  • Biotin-DEVD-FMK,
    DEVD-FMK, Biotin-

  • Z-DEVD-FMK,
    Caspase-3
    抑制劑(氟甲基酮)

  • Z-DEVD-FMK,
    Caspase-3
    抑制劑(氟甲基酮)




【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜 0920-312382 taiding.biotech@msa.hinet.net





【臺北公司】02-86609496【傳真】02-86609342





【相關網址】www.biopioneer.com.tw




【原廠網址】
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10X
Annexin V Binding Buffer





 


10x Annexin V Bingding Buffer





Catalog#: 1006-100 | Size: 100 ml





BioVision’s 10X Annexin V Binding
Buffer should be diluted to 1X with H
O before use.





Description: Buffer for use with the BioVision’s
Annexin V-FITC (Cat.# 1001-1000), Annexin V-Cy3 (Cat.# 1002-1000), Annexin
V-Cy5 (Cat.#1013-1000), Annexin V-EGFP (Cat.# 1004-1000), Annexin V-PE
(1014-1000), Annexin V-Biotin (Cat.# 1003-100), and Unlabeled Anenxin V (Cat.#
1005-100) reagents. During apoptosis, phosphatidylserine (PS) is translocated
from the cytoplasmic face of the plasma membrane to the cell surface. Annexin V
has a strong, Ca²
-dependent affinity for PS and
therefore serves as a probe for detecting apoptosis.





Storage Temp.: +4°C





【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜 0920-312382 taiding.biotech@msa.hinet.net





【臺北公司】02-86609496【傳真】02-86609342





【相關網址】www.biopioneer.com.tw




【原廠網址】
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Annexin V-Cy3
Reagent





Annexin V-Cy3 Reagent





Annexin V是一種Ca+依賴的磷脂結磷脂結合蛋白(35-36 kDa),

對磷脂絲氨酸(phosphatidylserine ;PS)具高度親和性。當細胞進行細胞凋亡(apoptosis)時,細胞膜的PS會外翻到外膜。Biovision提供一系列Annexin V細胞凋亡染劑。Annexin-V結合Cy3Cy7FITCR-PEPE/Cy7等不同波段染劑。直接應用於顯微鏡觀察及流氏細胞分析。





----Annexin
V
檢測試劑------





Catalog#: 1002-200 | Size: 200 assays





Product Highlights:

•Detection method- flow cytometry (Ex/Em- 543/570 nm) using FL2 channel and
fluorescence microscopy

•Sample- Cell culture

•Simple, easy to use and convenient





Description: The bright red color fluorescent
reagent for detecting of the early stages of apoptosis. During apoptosis,
phosphatidylserine (PS) is translocated from the cytoplasmic face of the plasma
membrane to the cell surface. Annexin V has a strong, Ca²
-dependent affinity for PS and therefore serves as a
probe for detecting apoptosis. The Annexin V-Cy3 conjugate contains the bright
red fluorescent probe that can be used for detection of apoptosis by
fluorescence microscopy with a rhodamine filter or by flow cytometry. Cy3
yields red fluorescence with a λmax emission of 570 nm.





Storage Temp.: +4°C





【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜 0920-312382 taiding.biotech@msa.hinet.net





【臺北公司】02-86609496【傳真】02-86609342





【相關網址】www.biopioneer.com.tw





【原廠網址】www.biovision.com





 


 

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Annexin
V-FITC Reagent





Catalog#: 1001-200 | Size: 200 assays





Annexin V-FITC Reagent




----Annexin V 檢測試劑------


Annexin V是一種Ca+依賴的磷脂結磷脂結合蛋白(35-36 kDa),

對磷脂絲氨酸(phosphatidylserine ;PS)具高度親和性。當細胞進行細胞凋亡(apoptosis)時,細胞膜的PS會外翻到外膜。Biovision提供一系列Annexin V細胞凋亡染劑。Annexin-V結合FITCR-PEPE/Cy7、Cy3Cy7等不同波段染劑。直接應用於顯微鏡觀察及流氏細胞分析。







Product
Highlights:


•Detection method- flow cytometry (Ex/ Em= 488 /530 nm) using FL1 channel and
fluorescence microscopy

•Sample- Cell culture

•Formulation- 0.15 mg/ml in PBS containing 1% BSA, 0.02% sodium azide

•Simple, easy to use and convenient





Description:
Reagent
for detecting early stages of apoptosis. During apoptosis, phosphatidylserine
(PS) is translocated from the cytoplasmic face of the plasma membrane to the
cell surface. Annexin V has a strong, Ca²
-dependent affinity for PS and therefore is used as a probe for
detecting apoptosis. The Annexin V-FITC conjugate can be used for detection of
apoptosis by fluorescence microscopy or by flow cytometry.





Storage
Temp.:
+4°C





【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜 0920-312382 taiding.biotech@msa.hinet.net





【臺北公司】02-86609496【傳真】02-86609342





【相關網址】www.biopioneer.com.tw




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Aposcreen 7-AAD






Technical Bulletin


訂購貨號# 10042-01


 






























Cat. No.




10042-01





Specificity




7-AAD





Applications




FC, FM





Format




UNLB





Size




100 tests





Volume




1


mL





 




【供應廠商】太鼎生物科技有限公司




【連絡人】許虹宜 0920-312382 taiding.biotech@msa.hinet.net




【臺北公司】02-86609496
【傳真】02-86609342




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Aposcreen Annexin V-FITC





Technical Bulletin


訂購貨號# 10039-02































Cat. No.




10039-02





Specificity




Annexin V





Applications




FC





Format




FITC





Size




100 tests





Volume




1


mL






 





【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜 0920-312382 taiding.biotech@msa.hinet.net





【臺北公司】02-86609496
【傳真】02-86609342





【相關網址】www.biopioneer.com.tw




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Necroptosis inhibitors抑制劑





Necroptosis Inhibitors




細胞死亡的主要方式有兩種:凋亡(apoptosis)和壞死(Necrosis)。凋亡是由細胞信號通路調控的死亡,而壞死是細胞對環境壓力的一種被動死亡方式。





哈佛大學醫學院的袁均英教授(Junying Yuan)和她的研究小組通過高通量的篩選方法,找出了一種抑制由細胞死亡因數引起的壞死的化學小分子necrostatin-1。這種小分子能專一性地阻斷細胞壞死,但對凋亡沒有抑制作用。這證明,壞死也能由精確的細胞信號通路來引起。這種死亡方式被他們命名為necroptosis。他們還發現,這種死亡方式在缺血性腦損傷的小鼠模型(a mouse model of ischemic brain injury)中扮演了重要角色。在今後Necroptosis的研究和中風(stroke)的治療上,necrostatin-1將是一個重要研究手段。





 





参考Chemical inhibitor of nonapoptotic cell
death with therapeutic potential for ischemic brain injury. Nature Chemical
Biology
1, 112-119 (2005)










































Catalog #




Product Name+




Size




1864-5




Necrostatin-1




5 mg




1864-25




Necrostatin-1




25 mg




1865-5




Necrostatin-5




5 mg




1865-25




Necrostatin-5




25 mg




1866-5




Necrostatin-7




5 mg




1866-25




Necrostatin-7




25 mg








【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜0920-312382 taiding.biotech@msa.hinet.net





【台北公司】02-86609496





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Mitochondrial分析套組











 



Mitochondrial Assays


 




Mitochondrial粒腺體分析套組】Biovision提供caspase activators相關產品,例如cytochrome c及膜電位改變之分析。貨號#k250-100K257-100


 



A variety of
key events in apoptosis focus on mitochondria, including the release of
caspase activators (such as cytochrome c), changes in electron transport,
loss of mitochondrial transmembrane potential, altered cellular
oxidationreduction, and participation of pro- and anti-apoptotic Bcl-2 family
proteins.
BioVision offers a number of products for detecting the
apoptosis related mitochondrial activity and changes by flow cytometry,
western blot, bioluminescence, fluorescence microscopy, and plate readers,
etc.



 


















































































Catalog #




Product Name+




Size




K255-200




ApoSENSOR™
ADP/ATP Ratio Assay Kit




200 assays




K254-1000




ApoSENSOR™
Cell Viability Assay Kit




1000 assays




K254-200




ApoSENSOR™
Cell Viability Assay Kit




200 assays




K257-100




Cytochrome
c Apoptosis Assay Kit




100 assays




K250-100




MitoCapture
Apoptosis Detection Kit




100 assays




K250-25




MitoCapture
Apoptosis Detection Kit




25 assays




K256-25




Mitochondria/Cytosol
Fractionation Kit




25 assays




K256-100




Mitochondria/Cytosol
Fractionation Kit




100 assays




K280-50




Mitochondrial
DNA Isolation Kit




50 assays




K791-100




StayBrite™
Highly Stable ATP Assay Kit




100 assays




K791-1000




StayBrite™
Highly Stable ATP Assay Kit




1000 assays




K790-100




StayBrite™
Highly Stable Luciferase/Luciferin Reagent




100 assays




K790-1000




StayBrite™
Highly Stable Luciferase/Luciferin Reagent




1000 assays




K790-10000




StayBrite™
Highly Stable Luciferase/Luciferin Reagent




10000 assays






 





【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜0920-312382 taiding.biotech@msa.hinet.net





【台北公司】02-86609496





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DNA片段分析套組





DNA片段分析套組】
BIOVISION
提供DNA片段分析套組,包括DNA Ladder assay分析(K170-50)TUNEL分析(K403-50)細胞凋亡檢測產品。





DNA Fragmentation





Nuclear mediated
apoptosis is characterized by chromatin condensation and progressive DNA cleavage
into low-molecular-weight fragments called DNA ladder.
BioVision offers
several novel kits for fast and sensitive detection of DNA ladder in apoptotic
cells. Unlike other similar kits on the market which require 1-2 days to
prepare nucleic acids, the new procedures require only 1-2 hours to prepare
chromosomal DNA. DNA ladders can easily be visualized by agarose gel
electrophoresis. The new Apoptotic DNA Ladder Isolation Kit can specifically
extract laddered DNA, making it work well for both tissue and cell samples. The
TUNEL-based DNA fragmentation assay kits provide complete components including
positive and negative control cells or tissue slides for convenient detection
of DNA fragmentation in cultured cells and tissue sections. Results can be analyzed
by flow cytometry or fluorescence microscopy.





Apoptotic DNA Ladder Assays





BioVision offers
three novel Apoptotic DNA Ladder Detection Kits. Quick Apoptotic DNA Ladder
Detection Kit offers fast detection of DNA fragmentation in apoptotic cells
. Unlike other
similar kits on the market which require 1-2 days to prepare nucleic acids, the
new procedure requires less than 90 minutes to prepare chromosomal DNA in a
single tube. The new procedure increases recovery of small fragmented DNA, and
therefore improves detection sensitivity. Enhanced Apoptotic DNA Ladder
Detection Kit incorporates a proprietary buffer system and a highly sensitive
staining dye, which dramatically increases the sensitivity of detection. The
newly released Apoptotic DNA ladder Isolation Kit can specifically extract DNA
ladder, giving the highest sensitivity. The kit can detect apoptotic DNA ladder
from both tissue and cells with as little as 5% apoptotic cell population. DNA
ladders can easily be visualized by agarose gel electrophoresis.



























Catalog #




Product Name+




Size




K170-50




Apoptotic
DNA Ladder Isolation Kit




50 assays




K130-50




Enhanced
Apoptotic DNA Ladder Detection Kit




50 assays




K120-50




Quick
Apoptotic DNA Ladder Detection Kit




50 assays






 





TUNEL Assays





 





BioVision offers four TUNEL-based In Situ DNA Fragmentation Assay
Kits.
All kits provide complete components including positive and
negative control cells or slides for convenient detection of DNA fragmentation
in cultured cells and tissue sections. The Apo-BrdUTM assay uses two-color
TUNEL method for detecting DNA strand breaks in apoptotic cells by flow
cytometer. The incorporation of BrdU in the procedure provides greater
sensitivity than biotinylated or digoxigenylated methods. The Apo-BrdU-RedTM
utilizes the same principle, but designed for GFP containing cells. The new
addition of ApoBrdU-IHCTM provides a complete kit for detecting DNA
fragmentation by dual color immunohistochemistry (IHC). The Apo-DIRECTTM assay
offers a simple one-step labeling of apoptotic cells which can be analyzed by
flow cytometry





 
































Catalog #




Product Name+




Size




K401-60




ApoBrdU
DNA Fragmentation Assay Kit




60 assays




K404-60




ApoBrdU
Red DNA Fragmentation Kit




60 assays




K403-50




ApoBrdU-IHC
DNA Fragmentation Assay Kit




50 assays




K402-50




ApoDIRECT
DNA Fragmentation Assay Kit




50 assays






 





【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜0920-312382 taiding.biotech@msa.hinet.net





【台北公司】02-86609496





【相關網址】www.biopioneer.com.tw




【原廠網址】
www.biovision.com


 


 


 

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Caspase 活性分析套組






Caspases




Caspase 活性分析套組】Biovisoin提供一系列細胞凋亡Caspase活性分析套組,產品種類包括Caspase12345678910111213活性分析套組。

Caspases are responsible for the deliberate
disassembly of the cell into apoptotic bodies during apoptosis.

Caspases are present as inactive pro-enzymes that are activated by proteolytic
cleavage. Caspases 8, 9, 12 and 3 are situated at pivotal junctions in
apoptosis pathways. Caspase 8 initiates disassembly in response to
extracellular apoptosis-inducing ligands and is activated in a complex
associated with the cytoplasmic death domain of many cell surface receptors for
the ligands. Caspase 9 activates disassembly in response to agents or insults
that trigger the release of cytochrome c from mitochondria and is activated
when complexed with apoptotic protease activating factor 1 (APAF-1) and
extra-mitochondrial cytochrome c. Caspase-12 appears to be activated by ER
stress. All three caspase pathways lead to caspase-3 activation. Caspase 3
amplifies caspase 8, caspase 9, and caspase-12 initiation signals into
full-fledged commitment to disassembly. Caspase 8 and caspase 9 activate
caspase 3 by proteolytic cleavage and caspase 3 then cleaves vital cellular
proteins or other caspases

 




Caspase-2
Caspase-3
Caspase-4
Caspase-5
Caspase-6
Caspase-7
Caspase-8
Caspase-9
Caspase-10
Caspase-11
Caspase-12
Caspase-13
Pan Caspases
Buffers and Control Lysates

 


 

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Caspase inhibitor抑制劑


 


Caspase Inhibitors





Caspase inhibitor抑制劑】 Biovision提供Caspase1/3/8/9等抑制劑。產品包括Z-ATAD-FMK Z-DEVD-FMKZ-IETD-FMKZ-LEHD-FMK Z-VAD-FMK Z-YVAD-FMK


 


 


















































































































Catalog #




Product Name+




Size




1160-1




Boc-D-FMK





1 mg




1160-5




Boc-D-FMK





5 mg




1674-5




SB-431542























5 mg




1152-1




Z-ATAD-FMK





1 mg




1152-5




Z-ATAD-FMK





5 mg




1143-1




Z-DEVD-FMK





1 mg




1143-5




Z-DEVD-FMK





5 mg




1148-1




Z-IETD-FMK





1 mg




1148-5




Z-IETD-FMK





5 mg




1149-1




Z-LEHD-FMK





1 mg




1149-5




Z-LEHD-FMK





5 mg




1144-1




Z-LEVD-FMK





1 mg




1144-5




Z-LEVD-FMK





5 mg




1140-1




Z-VAD-FMK





1 mg




1140-5




Z-VAD-FMK





5 mg




1142-1




Z-VDVAD-FMK





1 mg




1142-5




Z-VDVAD-FMK





5 mg




1146-1




Z-VEID-FMK





1 mg




1146-5




Z-VEID-FMK





5 mg




1141-1




Z-YVAD-FMK





1 mg




1141-5




Z-YVAD-FMK





5 mg






 





Next Generation Caspase Inhibitors







































Catalog #




Product Name+




Size




1175-1




Caspase-3
Inhibitor Q-DEVD-OPh




1 mg




1175-3




Caspase-3
Inhibitor Q-DEVD-OPh




3 mg




1175-5




Caspase-3
Inhibitor Q-DEVD-OPh




5 mg




1176-1




Caspase-8
Inhibitor, Q-IETD-OPh





1 mg




1176-3




Caspase-8
Inhibitor, Q-IETD-OPh





3 mg




1176-5




Caspase-8
Inhibitor, Q-IETD-OPh




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Autophagy分析套組





Biovision提供Autophagy inhibitor抑劑劑、inducers誘導劑、及相關抗體。





Autophagy works as a cellular
housekeeper by eliminating defective proteins and organelles, the prevention of
abnormal protein aggregate accumulation, and the removal of intracellular
pathogens. Such functions are likely critical for autophagy-mediated protection
against aging, cancer, neurodegenerative diseases, and infection. It is a bulk
degradation system that delivers cytoplasmic constituents into lysosomes and
the clearance of old/damaged organelles, long-lived proteins, insoluble protein
aggregates and lipid droplets. This enables the reuse of intracellular
constituents such as an amino acid pool during periods of starvation and
regulates cellular homeostasis, cell death/survival, and lipid metabolism.
Autophagy can be divided into three main forms: microautophagy,
chaperone-mediated autophagy and macroautophagy. In microautophagy and the
mammalian-specific chaperone-mediated autophagy the lysosome directly engulfs
small portions of cytosol or receives chaperone-associated cargoes, respectively.
Macroautophagy involves the autophagosome, a double-membrane-bound vesicle,
which fuses with a lysosome to form the autophagolysosome, which is responsible
for the turnover of organelles (e.g., mitochondria) and portions of cytosol.
Autophagosome formation is mediated by the coordinated action of
autophagy-related genes (Atg's). Studies in yeast have resulted in the
discovery of over 30 Atg's. More recent work has identified their mammalian
counterparts, such as ULK1 (Atg1), Atg3–5, beclin-1 (Atg6), Atg7, LC3 (Atg8),
Atg9a, Atg10, Atg12, Atg13L, Atg14L, Atg16L1, FIP200 (Atg17), and WIPI-1
(Atg18) and denote that Atg's are highly conserved between yeast and mammals.
Antigen presentation, innate immune signaling, and pathogen degradation may all
involve autophagosome recruitment and activity, which suggests autophagy, plays
an important role in immunity and defense against infectious diseases. However,
defects in the autophagic response has been linked to a significant number of
human pathological conditions, which in turn, have been linked to the mTOR,
PTEN/PI3-K, TLR pathways, and innate immune responses. Many neurodegenerative
conditions can be traced back to defects in the autophagic response. The role
of autophagy in Huntington's disease, Parkinson's disease, Amyotrophic lateral
sclerosis, or Alzheimer's disease may reside in the failure to clear aggregates
of mutated toxic proteins. Autophagy has also been identified as a crucial
process in oncogenesis and cancer progression. Several autophagy-related proteins
have tumor suppressor activities (Beclin-1, Atg5, Bif-1, Atg4C, and UVRAG).
Some mutations in the autophagy-related genes (detected in humans or induced in
cellular or animal models) appear to result in an accumulation of DNA damage
and genome instability. Several reports have suggested that later, as a tumor
grows, cancer cells may need autophagy to survive nutrient-limiting and
low-oxygen conditions, especially in the internal region of the tumor that is
poorly vascularized. Autophagy may also protect some cancer cells against
ionizing radiation, possibly by removing damaged macromolecules or organelles,
such as mitochondria, which could protect against apoptosis and allow continued
survival of transformed cells. BioVision offers wide range of autophagy
inducers and inhibitors as well as antibodies against autophagy related
proteins.





 





Autophagy Inducers





 










































Catalog #




Product Name+




Size




1828-100




Amiodarone
Hydrochloride




100 mg




1828-500




Amiodarone
Hydrochloride




500 mg




1686-5




Dorsomorphin




5 mg




1827-10




Rottlerin




10 mg




1856-5




SMER28




5 mg




1856-25




SMER28




25 mg






 





Autophagy Inhibitors





 

























































Catalog #




Product Name+




Size




1685-5




ATM
Kinase Inhibitor, KU-55933




5 mg




1829-50




Bafilomycin A1




50 µg




1829-250




Bafilomycin A1




250 µg




1825-100




Chloroquine
Diphosphate




100 mg




1825-500




Chloroquine
Diphosphate




500 mg




1785-500




EZSolution™ Gö
6976




500 µg




1711-500





6976




500 µg




2037-5




Spautin-1























5 mg




2037-25




Spautin-1





25 mg



 





Autophagy




























































Catalog #




Product Name+




Size




3113-100




AMPKα Antibody




100 µg




3110-100




AMPKα1 Antibody




100 µg




3169-100




AMPKα2 Antibody




100 µg




3117-100




AMPKα2 Antibody




100 µg




3910-100




APG10/ATG10
Antibody




100 µg




3912-100




APG12/ATG12
Antibody




100 µg




3912BP-50




APG12/ATG12
Blocking Peptide




50 µg




3916-100




APG16/ATG16
Antibody




100 µg




3916BP-50




APG16/ATG16
Blocking Peptide




50 µg




3886BP-50




Apg5/Atg
Blocking Peptide




 


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Apoptosis細胞萃取套組





Apoptotic Cell Isolation




應用Annexin V磁珠方式,萃取細胞中具有凋亡之細胞群,有效分離凋亡及未凋亡之細胞


BioVision's
Apoptotic Cell Isolation Kit provides simple and efficient means for isolation
of apoptotic cells from normal culture using annexin V magnetic beads
(MagBeads).
Binding of annexin V-biotin to
apoptotic cells followed by binding of the biotin to streptavidin-MagBeads
enables separation of apoptotic cells from normal cells. Apoptotic cells bound
to the MagBeads adhere to the magnet-while normal cells stay in suspension. The
bound apoptotic cells can then be released from the MagBeads using the Elution
Buffer provided in the kit. The separated apoptotic cells and normal cells can
be used in a variety of assays to study apoptotic mechanisms and pathways. The
kit has also been successfully used to remove dead cells from normal culture.






















Catalog #




Product Name+




Size




K258-30




Apoptotic Cell
Isolation Kit




30 isolation




2101-100




Sodium Chloride
Solution (NaCl)




100 ml (5M)









【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜0920-312382 taiding.biotech@msa.hinet.net





【台北公司】02-86609496





【相關網址】www.biopioneer.com.tw





【原廠網址】 www.biovision.com





 

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Apoptosis inducers細胞凋亡誘導劑





Apoptosis Inducers




BioVision提供高品質之Apoptosis
inducers
1000倍稀釋,ready-to-use 型式。


 These
selected apoptosis inducers have been well characterized that disrupt
mitochondrial transmembrane potential, activate caspases, induce
phosphatidyl-serine (PS) exposure, DNA fragmentation, and other apoptotic
characteristics. All inducers are ideally suited for use with various
BioVision’s apoptosis detection systems. Many high quality growth factors and
cytokines that are involved in apoptosis, as well as other chemicals in powder
form are also available separately.





Ready-to-Use Apoptosis Inducers & Sets










































Catalog #




Product Name+




Size




1036-50




Actinomycin D (10
mM)




50 µl




1039-1




Camptothecin (2 mM)




1 ml




1041-1




Cycloheximide
(100 mM)




1 ml




1042-1




Dexamethasone (10
mM)




1 ml




1043-100




Etoposide (100 mM)




100 µl




K121-5




Ready-to-use
Apoptosis Inducer Set




5 ready-to-use







Other Apoptosis Inducing Chemicals















































































































































































Catalog #



Product Name+



Size



1036-50MG



Actinomycin D



50 mg



1036-5MG



Actinomycin D



5 mg



1549-10



Anisomycin



10 mg



1830-100



Berberine
Chloride



100 mg



1830-500



Berberine
Chloride



500 mg



1552-25



Betulinic acid



25 mg



1560-50



Brefeldin A



50 mg



1560-5



Brefeldin A



5 mg



1039-500MG



Camptothecin



500 mg



1039-50MG



Camptothecin



50 mg



1553-100



Carboplatin



100 mg



1545-10G



CHAPS, High
Purity



10 g



1519-1000



Colchicine



1 g



1041-1G



Cycloheximide



1 g



1522-100



Cyclosporine A



100 mg



1524-500



Daunorubicin.HCl



500 mg



1524-10



Daunorubicin.HCl



10 mg



1524-50



Daunorubicin.HCl



50 mg



1042-10G



Dexamethasone



10 g



1042-1G



Dexamethasone



1 g



1527-5



Doxorubicin.HCl



5 mg



1043-250MG



Etoposide



250 mg



1043-25MG



Etoposide



25 mg



1531-5



Forskolin



5 mg



1561-50



Mifepristone



50 mg



1543-025



Okadaic acid



25 µg



1544-5



Phorbol-12-myristate
13-acetate (PMA)



5 mg



1568-5



Rapamycin



5 mg



1568-50



Rapamycin



50 mg



1551-1000



Tamoxifen
citrate



1 g



1571-5



Tyrphostin AG
1295



5 mg



1570-5



Tyrphostin AG
490



5 mg





 





【供應廠商】太鼎生物科技有限公司





【連絡人】許虹宜0920-312382 taiding.biotech@msa.hinet.net





【台北公司】02-86609496


 


 

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